Search Results

Overview

Uniprot ID	Q7Z5J4
Protein Name	Retinoic acid-induced protein 1
Gene Name	RAI1
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
1083	TTPAPPDKLGGKQRA
1159	TQEIFHSKRRRPSEG
1328	PRKGRGLKLEAIVQK
1335	KLEAIVQKITSPSLK
187	QQPLAYPKLQRQKLQ
77	AAAVAADKYHRGSKA
83	DKYHRGSKALPTQQG

Function

Transcriptional regulator of the circadian clock components: CLOCK, BMAL1, BMAL2, PER1/3, CRY1/2, NR1D1/2 and RORA/C. Positively regulates the transcriptional activity of CLOCK a core component of the circadian clock. Regulates transcription through chromatin remodeling by interacting with other proteins in chromatin as well as proteins in the basic transcriptional machinery. May be important for embryonic and postnatal development. May be involved in neuronal differentiation

Protein Sequence

10 MQSFRERCGF 20 HGKQQNYQQT 30 SQETSRLENY 40 RQPSQAGLSC 50 DRQRLLAKDY 60 YNPQPYPSYE 70 GGAGTPSGTA 80 AAVAADKYHR 90 GSKALPTQQG 100 LQGRPAFPGY 110 GVQDSSPYPG 120 RYAGEESLQA 130 WGAPQPPPPQ 140 PQPLPAGVAK 150 YDENLMKKTA 160 VPPSRQYAEQ 170 GAQVPFRTHS 180 LHVQQPPPPQ 190 QPLAYPKLQR 200 QKLQNDIASP 210 LPFPQGTHFP 220 QHSQSFPTSS 230 TYSSSVQGGG 240 QGAHSYKSCT 250 APTAQPHDRP 260 LTASSSLAPG 270 QRVQNLHAYQ 280 SGRLSYDQQQ 290 QQQQQQQQQQ 300 QALQSRHHAQ 310 ETLHYQNLAK 320 YQHYGQQGQG 330 YCQPDAAVRT 340 PEQYYQTFSP 350 SSSHSPARSV 360 GRSPSYSSTP 370 SPLMPNLENF 380 PYSQQPLSTG 390 AFPAGITDHS 400 HFMPLLNPSP 410 TDATSSVDTQ 420 AGNCKPLQKD 430 KLPENLLSDL 440 SLQSLTALTS 450 QVENISNTVQ 460 QLLLSKAAVP 470 QKKGVKNLVS 480 RTPEQHKSQH 490 CSPEGSGYSA 500 EPAGTPLSEP 510 PSSTPQSTHA 520 EPQEADYLSG 530 SEDPLERSFL 540 YCNQARGSPA 550 RVNSNSKAKP 560 ESVSTCSVTS 570 PDDMSTKSDD 580 SFQSLHGSLP 590 LDSFSKFVAG 600 ERDCPRLLLS 610 ALAQEDLASE 620 ILGLQEAIGE 630 KADKAWAEAP 640 SLVKDSSKPP 650 FSLENHSACL 660 DSVAKSAWPR 670 PGEPEALPDS 680 LQLDKGGNAK 690 DFSPGLFEDP 700 SVAFATPDPK 710 KTTGPLSFGT 720 KPTLGVPAPD 730 PTTAAFDCFP 740 DTTAASSADS 750 ANPFAWPEEN 760 LGDACPRWGL 770 HPGELTKGLE 780 QGGKASDGIS 790 KGDTHEASAC 800 LGFQEEDPPG 810 EKVASLPGDF 820 KQEEVGGVKE 830 EAGGLLQCPE 840 VAKADRWLED 850 SRHCCSTADF 860 GDLPLLPPTS 870 RKEDLEAEEE 880 YSSLCELLGS 890 PEQRPGMQDP 900 LSPKAPLICT 910 KEEVEEVLDS 920 KAGWGSPCHL 930 SGESVILLGP 940 TVGTESKVQS 950 WFESSLSHMK 960 PGEEGPDGER 970 APGDSTTSDA 980 SLAQKPNKPA 990 VPEAPIAKKE 1000 PVPRGKSLRS 1010 RRVHRGLPEA 1020 EDSPCRAPVL 1030 PKDLLLPESC 1040 TGPPQGQMEG 1050 AGAPGRGASE 1060 GLPRMCTRSL 1070 TALSEPRTPG 1080 PPGLTTTPAP 1090 PDKLGGKQRA 1100 AFKSGKRVGK 1110 PSPKAASSPS 1120 NPAALPVASD 1130 SSPMGSKTKE 1140 TDSPSTPGKD 1150 QRSMILRSRT 1160 KTQEIFHSKR 1170 RRPSEGRLPN 1180 CRATKKLLDN 1190 SHLPATFKVS 1200 SSPQKEGRVS 1210 QRARVPKPGA 1220 GSKLSDRPLH 1230 ALKRKSAFMA 1240 PVPTKKRNLV 1250 LRSRSSSSSN 1260 ASGNGGDGKE 1270 ERPEGSPTLF 1280 KRMSSPKKAK 1290 PTKGNGEPAT 1300 KLPPPETPDA 1310 CLKLASRAAF 1320 QGAMKTKVLP 1330 PRKGRGLKLE 1340 AIVQKITSPS 1350 LKKFACKAPG 1360 ASPGNPLSPS 1370 LSDKDRGLKG 1380 AGGSPVGVEE 1390 GLVNVGTGQK 1400 LPTSGADPLC 1410 RNPTNRSLKG 1420 KLMNSKKLSS 1430 TDCFKTEAFT 1440 SPEALQPGGT 1450 ALAPKKRSRK 1460 GRAGAHGLSK 1470 GPLEKRPYLG 1480 PALLLTPRDR 1490 ASGTQGASED 1500 NSGGGGKKPK 1510 MEELGLASQP 1520 PEGRPCQPQT 1530 RAQKQPGHTN 1540 YSSYSKRKRL 1550 TRGRAKNTTS 1560 SPCKGRAKRR 1570 RQQQVLPLDP 1580 AEPEIRLKYI 1590 SSCKRLRSDS 1600 RTPAFSPFVR 1610 VEKRDAFTTI 1620 CTVVNSPGDA 1630 PKPHRKPSSS 1640 ASSSSSSSSF 1650 SLDAAGASLA 1660 TLPGGSILQP 1670 RPSLPLSSTM 1680 HLGPVVSKAL 1690 STSCLVCCLC 1700 QNPANFKDLG 1710 DLCGPYYPEH 1720 CLPKKKPKLK 1730 EKVRPEGTCE 1740 EASLPLERTL 1750 KGPECAAAAT 1760 AGKPPRPDGP 1770 ADPAKQGPLR 1780 TSARGLSRRL 1790 QSCYCCDGRE 1800 DGGEEAAPAD 1810 KGRKHECSKE 1820 APAEPGGEAQ 1830 EHWVHEACAV 1840 WTGGVYLVAG 1850 KLFGLQEAMK 1860 VAVDMMCSSC 1870 QEAGATIGCC 1880 HKGCLHTYHY 1890 PCASDAGCIF 1900 IEENFSLKCP KHKRLP

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0005654	nucleoplasm
Cellular Component	GO:0005634	nucleus
Molecular Function	GO:0003712	transcription coregulator activity
Molecular Function	GO:0008270	zinc ion binding
Biological Process	GO:0032922	circadian regulation of gene expression
Biological Process	GO:0045893	positive regulation of DNA-templated transcription
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[3] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.