Search Results

Overview

Uniprot IDQ7Z5L9
Protein NameInterferon regulatory factor 2-binding protein 2
Gene NameIRF2BP2
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
236 PTDLGAHKRPASVSS
289 LSAEGAGKSRGSGEQ
303 QDWVNRPKTVRDTLL
324 HSGPFESKFKKEPAL
326 GPFESKFKKEPALTA
348 ANGANGSKAVARTAR

Function

Acts as a transcriptional corepressor in a IRF2-dependent manner; this repression is not mediated by histone deacetylase activities (PubMed:12799427). Represses the NFAT1-dependent transactivation of NFAT-responsive promoters (PubMed:21576369). Acts as a coactivator of VEGFA expression in cardiac and skeletal muscles (PubMed:20702774). Plays a role in immature B-cell differentiation (PubMed:27016798)

Protein Sequence

10 MAAAVAVAAA 20 SRRQSCYLCD 30 LPRMPWAMIW 40 DFTEPVCRGC 50 VNYEGADRVE 60 FVIETARQLK 70 RAHGCFPEGR 80 SPPGAAASAA 90 AKPPPLSAKD 100 ILLQQQQQLG 110 HGGPEAAPRA 120 PQALERYPLA 130 AAAERPPRLG 140 SDFGSSRPAA 150 SLAQPPTPQP 160 PPVNGILVPN 170 GFSKLEEPPE 180 LNRQSPNPRR 190 GHAVPPTLVP 200 LMNGSATPLP 210 TALGLGGRAA 220 ASLAAVSGTA 230 AASLGSAQPT 240 DLGAHKRPAS 250 VSSSAAVEHE 260 QREAAAKEKQ 270 PPPPAHRGPA 280 DSLSTAAGAA 290 ELSAEGAGKS 300 RGSGEQDWVN 310 RPKTVRDTLL 320 ALHQHGHSGP 330 FESKFKKEPA 340 LTAGRLLGFE 350 ANGANGSKAV 360 ARTARKRKPS 370 PEPEGEVGPP 380 KINGEAQPWL 390 STSTEGLKIP 400 MTPTSSFVSP 410 PPPTASPHSN 420 RTTPPEAAQN 430 GQSPMAALIL 440 VADNAGGSHA 450 SKDANQVHST 460 TRRNSNSPPS 470 PSSMNQRRLG 480 PREVGGQGAG 490 NTGGLEPVHP 500 ASLPDSSLAT 510 SAPLCCTLCH 520 ERLEDTHFVQ 530 CPSVPSHKFC 540 FPCSRQSIKQ 550 QGASGEVYCP 560 SGEKCPLVGS 570 NVPWAFMQGE 580 IATILAGDVK VKKERDS

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Molecular Function GO:0003714 transcription corepressor activity
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0002327 immature B cell differentiation
Biological Process GO:0000122 negative regulation of transcription by RNA polymerase II
Biological Process GO:0006357 regulation of transcription by RNA polymerase II

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[4] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[5] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[6] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.