Search Results
Overview
| Uniprot ID | Q7Z5P4 |
|---|---|
| Protein Name | 17-beta-hydroxysteroid dehydrogenase 13 |
| Gene Name | HSD17B13 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 108 | YRSLNQVKKEVGDVT |
| 208 | SELQALGKTGIKTSC |
| 212 | ALGKTGIKTSCLCPV |
| 227 | FVNTGFTKNPSTRLW |
| 254 | IDGILTNKKMIFVPS |
| 271 | NIFLRLQKFLPERAS |
| 32 | FFIPQRRKSVAGEIV |
| 58 | QTTYEFAKRQSILVL |
| 70 | LVLWDINKRGVEETA |
Function
Plays a pivotal role in hepatic lipid metabolism (PubMed:29562163). In vitro, it catalyzes the oxidation of a variety of lipid substrates, including 17beta-estradiol, retinol, retinal, and leukotriene B4 (PubMed:29562163, PubMed:30415504, PubMed:32973038)
Protein Sequence
10
MNIILEILLL
20
LITIIYSYLE
30
SLVKFFIPQR
40
RKSVAGEIVL
50
ITGAGHGIGR
60
QTTYEFAKRQ
70
SILVLWDINK
80
RGVEETAAEC
90
RKLGVTAHAY
100
VVDCSNREEI
110
YRSLNQVKKE
120
VGDVTIVVNN
130
AGTVYPADLL
140
STKDEEITKT
150
FEVNILGHFW
160
ITKALLPSMM
170
ERNHGHIVTV
180
ASVCGHEGIP
190
YLIPYCSSKF
200
AAVGFHRGLT
210
SELQALGKTG
220
IKTSCLCPVF
230
VNTGFTKNPS
240
TRLWPVLETD
250
EVVRSLIDGI
260
LTNKKMIFVP
270
SYINIFLRLQ
280
KFLPERASAI
290
LNRMQNIQFE
300
AVVGHKIKMK
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005783 | endoplasmic reticulum |
| Cellular Component | GO:0005811 | lipid droplet |
| Molecular Function | GO:0004745 | all-trans-retinol dehydrogenase (NAD+) activity |
| Molecular Function | GO:0004303 | estradiol 17-beta-dehydrogenase [NAD(P)+] activity |
| Molecular Function | GO:0120013 | lipid transfer activity |
| Molecular Function | GO:0016616 | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| Molecular Function | GO:0016229 | steroid dehydrogenase activity |
| Biological Process | GO:0034389 | lipid droplet organization |
| Biological Process | GO:0006629 | lipid metabolic process |
| Biological Process | GO:0046889 | positive regulation of lipid biosynthetic process |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.