Search Results

Overview

Uniprot ID	Q7Z5R6
Protein Name	Amyloid beta A4 precursor protein-binding family B member 1-interacting protein
Gene Name	APBB1IP
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
344	SGIYYVPKGKTKTSR
537	GSPATPLKAKGTGGG

Function

Appears to function in the signal transduction from Ras activation to actin cytoskeletal remodeling. Suppresses insulin-induced promoter activities through AP1 and SRE. Mediates Rap1-induced adhesion

Protein Sequence

10 MGESSEDIDQ 20 MFSTLLGEMD 30 LLTQSLGVDT 40 LPPPDPNPPR 50 AEFNYSVGFK 60 DLNESLNALE 70 DQDLDALMAD 80 LVADISEAEQ 90 RTIQAQKESL 100 QNQHHSASLQ 110 ASIFSGAASL 120 GYGTNVAATG 130 ISQYEDDLPP 140 PPADPVLDLP 150 LPPPPPEPLS 160 QEEEEAQAKA 170 DKIKLALEKL 180 KEAKVKKLVV 190 KVHMNDNSTK 200 SLMVDERQLA 210 RDVLDNLFEK 220 THCDCNVDWC 230 LYEIYPELQI 240 ERFFEDHENV 250 VEVLSDWTRD 260 TENKILFLEK 270 EEKYAVFKNP 280 QNFYLDNRGK 290 KESKETNEKM 300 NAKNKESLLE 310 ESFCGTSIIV 320 PELEGALYLK 330 EDGKKSWKRR 340 YFLLRASGIY 350 YVPKGKTKTS 360 RDLACFIQFE 370 NVNIYYGTQH 380 KMKYKAPTDY 390 CFVLKHPQIQ 400 KESQYIKYLC 410 CDDTRTLNQW 420 VMGIRIAKYG 430 KTLYDNYQRA 440 VAKAGLASRW 450 TNLGTVNAAA 460 PAQPSTGPKT 470 GTTQPNGQIP 480 QATHSVSAVL 490 QEAQRHAETS 500 KDKKPALGNH 510 HDPAVPRAPH 520 APKSSLPPPP 530 PVRRSSDTSG 540 SPATPLKAKG 550 TGGGGLPAPP 560 DDFLPPPPPP 570 PPLDDPELPP 580 PPPDFMEPPP 590 DFVPPPPPSY 600 AGIAGSELPP 610 PPPPPPAPAP 620 APVPDSARPP 630 PAVAKRPPVP 640 PKRQENPGHP 650 GGAGGGEQDF 660 MSDLMKALQK KRGNVS

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005856	cytoskeleton
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0005925	focal adhesion
Cellular Component	GO:0030027	lamellipodium
Cellular Component	GO:0005886	plasma membrane
Cellular Component	GO:0042101	T cell receptor complex
Molecular Function	GO:0030674	protein-macromolecule adaptor activity
Biological Process	GO:0035556	intracellular signal transduction

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.

[3] Yang YH, Wang QC, Kong J, Yang JT, Liu JF. Global profiling of lysine lactylation in human lungs.. Proteomics 23(15):e2200437. 2023 Aug. PMID: 37170646.

[4] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.

[5] Hu J, Jin Z, Gao Y, Liu Q, Yu Y et al.. Global Profiling of Lactylation Proteomics and Specific Lactylated Site Validation in Rheumatoid Arthritis Patients.. J Proteome Res 24(4):1732-1744. 2025 Apr 4. PMID: 40112136.