Search Results

Overview

Uniprot ID	Q7Z6B7
Protein Name	SLIT-ROBO Rho GTPase-activating protein 1
Gene Name	SRGAP1
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
929	SRHDSLKKIDSPPIR

Function

GTPase-activating protein for RhoA and Cdc42 small GTPases. Together with CDC42 seems to be involved in the pathway mediating the repulsive signaling of Robo and Slit proteins in neuronal migration. SLIT2, probably through interaction with ROBO1, increases the interaction of SRGAP1 with ROBO1 and inactivates CDC42

Protein Sequence

10 MSTPSRFKKD 20 KEIIAEYESQ 30 VKEIRAQLVE 40 QQKCLEQQTE 50 MRVQLLQDLQ 60 DFFRKKAEIE 70 TEYSRNLEKL 80 AERFMAKTRS 90 TKDHQQYKKD 100 QNLLSPVNCW 110 YLLLNQVRRE 120 SKDHATLSDI 130 YLNNVIMRFM 140 QISEDSTRMF 150 KKSKEIAFQL 160 HEDLMKVLNE 170 LYTVMKTYHM 180 YHAESISAES 190 KLKEAEKQEE 200 KQIGRSGDPV 210 FHIRLEERHQ 220 RRSSVKKIEK 230 MKEKRQAKYS 240 ENKLKSIKAR 250 NEYLLTLEAT 260 NASVFKYYIH 270 DLSDLIDCCD 280 LGYHASLNRA 290 LRTYLSAEYN 300 LETSRHEGLD 310 IIENAVDNLE 320 PRSDKQRFME 330 MYPAAFCPPM 340 KFEFQSHMGD 350 EVCQVSAQQP 360 VQAELMLRYQ 370 QLQSRLATLK 380 IENEEVKKTT 390 EATLQTIQDM 400 VTIEDYDVSE 410 CFQHSRSTES 420 VKSTVSETYL 430 SKPSIAKRRA 440 NQQETEQFYF 450 MKLREYLEGS 460 NLITKLQAKH 470 DLLQRTLGEG 480 HRAEYMTTRP 490 PNVPPKPQKH 500 RKSRPRSQYN 510 TKLFNGDLET 520 FVKDSGQVIP 530 LIVESCIRFI 540 NLYGLQHQGI 550 FRVSGSQVEV 560 NDIKNSFERG 570 ENPLADDQSN 580 HDINSVAGVL 590 KLYFRGLENP 600 LFPKERFNDL 610 ISCIRIDNLY 620 ERALHIRKLL 630 LTLPRSVLIV 640 MRYLFAFLNH 650 LSQYSDENMM 660 DPYNLAICFG 670 PTLMPVPEIQ 680 DQVSCQAHVN 690 EIIKTIIIHH 700 ETIFPDAKEL 710 DGPVYEKCMA 720 GDDYCDSPYS 730 EHGTLEEVDQ 740 DAGTEPHTSE 750 DECEPIEAIA 760 KFDYVGRSAR 770 ELSFKKGASL 780 LLYHRASEDW 790 WEGRHNGIDG 800 LVPHQYIVVQ 810 DMDDTFSDTL 820 SQKADSEASS 830 GPVTEDKSSS 840 KDMNSPTDRH 850 PDGYLARQRK 860 RGEPPPPVRR 870 PGRTSDGHCP 880 LHPPHALSNS 890 SVDLGSPSLA 900 SHPRGLLQNR 910 GLNNDSPERR 920 RRPGHGSLTN 930 ISRHDSLKKI 940 DSPPIRRSTS 950 SGQYTGFNDH 960 KPLDPETIAQ 970 DIEETMNTAL 980 NELRELERQS 990 TAKHAPDVVL 1000 DTLEQVKNSP 1010 TPATSTESLS 1020 PLHNVALRSS 1030 EPQIRRSTSS 1040 SSDTMSTFKP 1050 MVAPRMGVQL 1060 KPPALRPKPA 1070 VLPKTNPTIG 1080 PAPPPQGPTD KSCTM

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005829	cytosol
Molecular Function	GO:0005096	GTPase activator activity
Molecular Function	GO:0031267	small GTPase binding
Biological Process	GO:0030336	negative regulation of cell migration
Biological Process	GO:0007399	nervous system development
Biological Process	GO:0051963	regulation of synapse assembly
Biological Process	GO:0007165	signal transduction

Reference

[1] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.