Search Results

Overview

Uniprot IDQ7Z6E9
Protein NameE3 ubiquitin-protein ligase RBBP6
Gene NameRBBP6
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
1039 ENIVKPAKGPQEKVD
1122 SKDVKSEKLTTKEEK
1169 SSSMKISKLEVTEIV
1183 VKPSPKRKMEPDTEK
1207 ISLSAPAKKIKLNRE
1208 SLSAPAKKIKLNRET
1218 LNRETGKKIGSTENI
1350 GKPASVIKNVSTKPS
1361 TKPSNIVKYPEKESE
1378 EKIQKFTKDVSHEII
1390 EIIQHEVKSSKNSAS
1441 LNEQGNFKSLSQSSK
1465 STRASSNKDFTPNRD
1552 HKATYDTKRPNEETK
190 ESGPRIKKSTGIPRS
203 RSFMMEVKDPNMKGA
232 AEAYAIGKKEKPPFL
233 EAYAIGKKEKPPFLP
334 GYTKRLRKQLPPPPP
435 PFRDSDNKILPAAAL
657 EEEKKKSKLDEFTND
81 RIPIGGVKSTSKTYV
85 GGVKSTSKTYVISRT
901 IGSNYPEKLSARDGH
941 KKHRKRRKGEESEGF

Function

E3 ubiquitin-protein ligase which promotes ubiquitination of YBX1, leading to its degradation by the proteasome (PubMed:18851979). May play a role as a scaffold protein to promote the assembly of the p53/TP53-MDM2 complex, resulting in increase of MDM2-mediated ubiquitination and degradation of p53/TP53; may function as negative regulator of p53/TP53, leading to both apoptosis and cell growth (By similarity). Regulates DNA-replication and the stability of chromosomal common fragile sites (CFSs) in a ZBTB38- and MCM10-dependent manner. Controls ZBTB38 protein stability and abundance via ubiquitination and proteasomal degradation, and ZBTB38 in turn negatively regulates the expression of MCM10 which plays an important role in DNA-replication (PubMed:24726359)

Protein Sequence

10 MSCVHYKFSS 20 KLNYDTVTFD 30 GLHISLCDLK 40 KQIMGREKLK 50 AADCDLQITN 60 AQTKEEYTDD 70 NALIPKNSSV 80 IVRRIPIGGV 90 KSTSKTYVIS 100 RTEPAMATTK 110 AIDDSSASIS 120 LAQLTKTANL 130 AEANASEEDK 140 IKAMMSQSGH 150 EYDPINYMKK 160 PLGPPPPSYT 170 CFRCGKPGHY 180 IKNCPTNGDK 190 NFESGPRIKK 200 STGIPRSFMM 210 EVKDPNMKGA 220 MLTNTGKYAI 230 PTIDAEAYAI 240 GKKEKPPFLP 250 EEPSSSSEED 260 DPIPDELLCL 270 ICKDIMTDAV 280 VIPCCGNSYC 290 DECIRTALLE 300 SDEHTCPTCH 310 QNDVSPDALI 320 ANKFLRQAVN 330 NFKNETGYTK 340 RLRKQLPPPP 350 PPIPPPRPLI 360 QRNLQPLMRS 370 PISRQQDPLM 380 IPVTSSSTHP 390 APSISSLTSN 400 QSSLAPPVSG 410 NPSSAPAPVP 420 DITATVSISV 430 HSEKSDGPFR 440 DSDNKILPAA 450 ALASEHSKGT 460 SSIAITALME 470 EKGYQVPVLG 480 TPSLLGQSLL 490 HGQLIPTTGP 500 VRINTARPGG 510 GRPGWEHSNK 520 LGYLVSPPQQ 530 IRRGERSCYR 540 SINRGRHHSE 550 RSQRTQGPSL 560 PATPVFVPVP 570 PPPLYPPPPH 580 TLPLPPGVPP 590 PQFSPQFPPG 600 QPPPAGYSVP 610 PPGFPPAPAN 620 LSTPWVSSGV 630 QTAHSNTIPT 640 TQAPPLSREE 650 FYREQRRLKE 660 EEKKKSKLDE 670 FTNDFAKELM 680 EYKKIQKERR 690 RSFSRSKSPY 700 SGSSYSRSSY 710 TYSKSRSGST 720 RSRSYSRSFS 730 RSHSRSYSRS 740 PPYPRRGRGK 750 SRNYRSRSRS 760 HGYHRSRSRS 770 PPYRRYHSRS 780 RSPQAFRGQS 790 PNKRNVPQGE 800 TEREYFNRYR 810 EVPPPYDMKA 820 YYGRSVDFRD 830 PFEKERYREW 840 ERKYREWYEK 850 YYKGYAAGAQ 860 PRPSANRENF 870 SPERFLPLNI 880 RNSPFTRGRR 890 EDYVGGQSHR 900 SRNIGSNYPE 910 KLSARDGHNQ 920 KDNTKSKEKE 930 SENAPGDGKG 940 NKHKKHRKRR 950 KGEESEGFLN 960 PELLETSRKS 970 REPTGVEENK 980 TDSLFVLPSR 990 DDATPVRDEP 1000 MDAESITFKS 1010 VSEKDKRERD 1020 KPKAKGDKTK 1030 RKNDGSAVSK 1040 KENIVKPAKG 1050 PQEKVDGERE 1060 RSPRSEPPIK 1070 KAKEETPKTD 1080 NTKSSSSSQK 1090 DEKITGTPRK 1100 AHSKSAKEHQ 1110 ETKPVKEEKV 1120 KKDYSKDVKS 1130 EKLTTKEEKA 1140 KKPNEKNKPL 1150 DNKGEKRKRK 1160 TEEKGVDKDF 1170 ESSSMKISKL 1180 EVTEIVKPSP 1190 KRKMEPDTEK 1200 MDRTPEKDKI 1210 SLSAPAKKIK 1220 LNRETGKKIG 1230 STENISNTKE 1240 PSEKLESTSS 1250 KVKQEKVKGK 1260 VRRKVTGTEG 1270 SSSTLVDYTS 1280 TSSTGGSPVR 1290 KSEEKTDTKR 1300 TVIKTMEEYN 1310 NDNTAPAEDV 1320 IIMIQVPQSK 1330 WDKDDFESEE 1340 EDVKSTQPIS 1350 SVGKPASVIK 1360 NVSTKPSNIV 1370 KYPEKESEPS 1380 EKIQKFTKDV 1390 SHEIIQHEVK 1400 SSKNSASSEK 1410 GKTKDRDYSV 1420 LEKENPEKRK 1430 NSTQPEKESN 1440 LDRLNEQGNF 1450 KSLSQSSKEA 1460 RTSDKHDSTR 1470 ASSNKDFTPN 1480 RDKKTDYDTR 1490 EYSSSKRRDE 1500 KNELTRRKDS 1510 PSRNKDSASG 1520 QKNKPREERD 1530 LPKKGTGDSK 1540 KSNSSPSRDR 1550 KPHDHKATYD 1560 TKRPNEETKS 1570 VDKNPCKDRE 1580 KHVLEARNNK 1590 ESSGNKLLYI 1600 LNPPETQVEK 1610 EQITGQIDKS 1620 TVKPKPQLSH 1630 SSRLSSDLTR 1640 ETDEAAFEPD 1650 YNESDSESNV 1660 SVKEEESSGN 1670 ISKDLKDKIV 1680 EKAKESLDTA 1690 AVVQVGISRN 1700 QSHSSPSVSP 1710 SRSHSPSGSQ 1720 TRSHSSSASS 1730 AESQDSKKKK 1740 KKKEKKKHKK 1750 HKKHKKHKKH 1760 AGTEVELEKS 1770 QKHKHKKKKS 1780 KKNKDKEKEK 1790 EKDDQKVKSV TV

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005813 centrosome
Cellular Component GO:0005694 chromosome
Cellular Component GO:0005829 cytosol
Cellular Component GO:0016607 nuclear speck
Cellular Component GO:0005730 nucleolus
Cellular Component GO:0005634 nucleus
Cellular Component GO:0032991 protein-containing complex
Molecular Function GO:0019901 protein kinase binding
Molecular Function GO:0003723 RNA binding
Molecular Function GO:0061630 ubiquitin protein ligase activity
Molecular Function GO:0004842 ubiquitin-protein transferase activity
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0006974 DNA damage response
Biological Process GO:0006260 DNA replication
Biological Process GO:0006397 mRNA processing
Biological Process GO:0016567 protein ubiquitination
Biological Process GO:0006275 regulation of DNA replication
Biological Process GO:0006511 ubiquitin-dependent protein catabolic process

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[4] Bao Q, Wan N, He Z, Cao J, Yuan W et al.. Subcellular Proteomic Mapping of Lysine Lactylation.. J Am Soc Mass Spectrom 35(12):3221-3232. 2024 Dec 4. PMID: 39569522.

[5] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[6] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.