Search Results

Overview

Uniprot ID	Q7Z6K5
Protein Name	Arpin
Gene Name	ARPIN
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
101	GFLMSSYKVEAKGDT
105	SSYKVEAKGDTDRLT
13	HDGALRNKAVQSVRL
182	LEAGTVTKCNFTGDG
203	TDNIMAQKCSKGAAA
206	IMAQKCSKGAAAEIR
90	PNFSATRKVNTGFLM

Function

Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex; the function is competitive with nucleation promoting factors. Participates in an incoherent feedforward loop at the lamellipodium tip where it inhibits the ARP2/2 complex in response to Rac signaling and where Rac also stimulates actin polymerization through the WAVE complex. Involved in steering cell migration by controlling its directional persistence

Protein Sequence

10 MSRIYHDGAL 20 RNKAVQSVRL 30 PGAWDPAAHQ 40 GGNGVLLEGE 50 LIDVSRHSIL 60 DTHGRKERYY 70 VLYIRPSHIH 80 RRKFDAKGNE 90 IEPNFSATRK 100 VNTGFLMSSY 110 KVEAKGDTDR 120 LTPEALKGLV 130 NKPELLALTE 140 SLTPDHTVAF 150 WMPESEMEVM 160 ELELGAGVRL 170 KTRGDGPFLD 180 SLAKLEAGTV 190 TKCNFTGDGK 200 TGASWTDNIM 210 AQKCSKGAAA 220 EIREQGDGAE DEEWDD

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0030027	lamellipodium
Biological Process	GO:0033058	directional locomotion
Biological Process	GO:0051126	negative regulation of actin nucleation
Biological Process	GO:0030336	negative regulation of cell migration
Biological Process	GO:2000393	negative regulation of lamellipodium morphogenesis

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[4] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.

[5] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[6] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.