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Overview

Uniprot IDQ7Z6M1
Protein NameRab9 effector protein with kelch motifs
Gene NameRABEPK
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
2 ******MKQLPVLEP

Function

Rab9 effector required for endosome to trans-Golgi network (TGN) transport

Protein Sequence

10 MKQLPVLEPG 20 DKPRKATWYT 30 LTVPGDSPCA 40 RVGHSCSYLP 50 PVGNAKRGKV 60 FIVGGANPNR 70 SFSDVHTMDL 80 GKHQWDLDTC 90 KGLLPRYEHA 100 SFIPSCTPDR 110 IWVFGGANQS 120 GNRNCLQVLN 130 PETRTWTTPE 140 VTSPPPSPRT 150 FHTSSAAIGN 160 QLYVFGGGER 170 GAQPVQDTKL 180 HVFDANTLTW 190 SQPETLGNPP 200 SPRHGHVMVA 210 AGTKLFIHGG 220 LAGDRFYDDL 230 HCIDISDMKW 240 QKLNPTGAAP 250 AGCAAHSAVA 260 MGKHVYIFGG 270 MTPAGALDTM 280 YQYHTEEQHW 290 TLLKFDTLLP 300 PGRLDHSMCI 310 IPWPVTCASE 320 KEDSNSLTLN 330 HEAEKEDSAD 340 KVMSHSGDSH 350 EESQTATLLC 360 LVFGGMNTEG 370 EIYDDCIVTV VD

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005768 endosome
Cellular Component GO:0010008 endosome membrane
Cellular Component GO:0032588 trans-Golgi network membrane
Cellular Component GO:0030133 transport vesicle
Biological Process GO:0006898 receptor-mediated endocytosis
Biological Process GO:0006904 vesicle docking involved in exocytosis

Reference

[1] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.

[2] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.