Overview
| Uniprot ID | Q7Z7C8 |
|---|
| Protein Name | Transcription initiation factor TFIID subunit 8 |
|---|
| Gene Name | TAF8 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 20 |
SGTRSGSKQSTNPAD |
Function
The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription (PubMed:33795473). TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC) (PubMed:33795473). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13 (PubMed:33795473). The TFIID complex structure can be divided into 3 modules TFIID-A, TFIID-B, and TFIID-C (PubMed:33795473). TAF8 is involved in forming the TFIID-B module, together with TAF5 (PubMed:33795473). Mediates both basal and activator-dependent transcription (PubMed:14580349). Plays a role in the differentiation of preadipocyte fibroblasts to adipocytes, however, does not seem to play a role in differentiation of myoblasts (PubMed:14580349). Required for the integration of TAF10 in the TAF complex (PubMed:14580349). May be important for survival of cells of the inner cell mass which constitute the pluripotent cell population of the early embryo (By similarity)
Protein Sequence
10
MADAAATAGA
20
GGSGTRSGSK
30
QSTNPADNYH
40
LARRRTLQVV
50
VSSLLTEAGF
60
ESAEKASVET
70
LTEMLQSYIS
80
EIGRSAKSYC
90
EHTARTQPTL
100
SDIVVTLVEM
110
GFNVDTLPAY
120
AKRSQRMVIT
130
APPVTNQPVT
140
PKALTAGQNR
150
PHPPHIPSHF
160
PEFPDPHTYI
170
KTPTYREPVS
180
DYQVLREKAA
190
SQRRDVERAL
200
TRFMAKTGET
210
QSLFKDDVST
220
FPLIAARPFT
230
IPYLTALLPS
240
ELEMQQMEET
250
DSSEQDEQTD
260
TENLALHISM
270
EDSGAEKENT
280
SVLQQNPSLS
290
GSRNGEENII
300
DNPYLRPVKK
310
PKIRRKKSLS
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005654 |
nucleoplasm |
| Cellular Component |
GO:0005634 |
nucleus |
| Cellular Component |
GO:0048471 |
perinuclear region of cytoplasm |
| Cellular Component |
GO:0005669 |
transcription factor TFIID complex |
| Molecular Function |
GO:0046982 |
protein heterodimerization activity |
| Molecular Function |
GO:0016251 |
RNA polymerase II general transcription initiation factor activity |
| Biological Process |
GO:0030154 |
cell differentiation |
| Biological Process |
GO:0001112 |
DNA-templated transcription open complex formation |
| Biological Process |
GO:0051457 |
maintenance of protein location in nucleus |
| Biological Process |
GO:0042789 |
mRNA transcription by RNA polymerase II |
| Biological Process |
GO:0060261 |
positive regulation of transcription initiation by RNA polymerase II |
| Biological Process |
GO:0045598 |
regulation of fat cell differentiation |
| Biological Process |
GO:0051123 |
RNA polymerase II preinitiation complex assembly |
| Biological Process |
GO:0006367 |
transcription initiation at RNA polymerase II promoter |
Reference
PMID: N/A