Search Results
Overview
| Uniprot ID | Q7Z7F0 |
|---|---|
| Protein Name | KH homology domain-containing protein 4 |
| Gene Name | KHDC4 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 461 | PSQPQAQKRRFTEEL |
| 75 | AMLMAKGKLKPTQNA |
| 91 | EKLQAPGKGLTSNKS |
Function
RNA-binding protein involved in pre-mRNA splicing (PubMed:19641227). Interacts with the PRP19C/Prp19 complex/NTC/Nineteen complex which is part of the spliceosome (PubMed:19641227). Involved in regulating splice site selection (PubMed:19641227). Binds preferentially RNA with A/C rich sequences and poly-C stretches (PubMed:23144703)
Protein Sequence
10
MSAGSATHPG
20
AGGRRSKWDQ
30
PAPAPLLFLP
40
PAAPGGEVTS
50
SGGSPGGTTA
60
APSGALDAAA
70
AVAAKINAML
80
MAKGKLKPTQ
90
NASEKLQAPG
100
KGLTSNKSKD
110
DLVVAEVEIN
120
DVPLTCRNLL
130
TRGQTQDEIS
140
RLSGAAVSTR
150
GRFMTTEEKA
160
KVGPGDRPLY
170
LHVQGQTREL
180
VDRAVNRIKE
190
IITNGVVKAA
200
TGTSPTFNGA
210
TVTVYHQPAP
220
IAQLSPAVSQ
230
KPPFQSGMHY
240
VQDKLFVGLE
250
HAVPTFNVKE
260
KVEGPGCSYL
270
QHIQIETGAK
280
VFLRGKGSGC
290
IEPASGREAF
300
EPMYIYISHP
310
KPEGLAAAKK
320
LCENLLQTVH
330
AEYSRFVNQI
340
NTAVPLPGYT
350
QPSAISSVPP
360
QPPYYPSNGY
370
QSGYPVVPPP
380
QQPVQPPYGV
390
PSIVPPAVSL
400
APGVLPALPT
410
GVPPVPTQYP
420
ITQVQPPAST
430
GQSPMGGPFI
440
PAAPVKTALP
450
AGPQPQPQPQ
460
PPLPSQPQAQ
470
KRRFTEELPD
480
ERESGLLGYQ
490
HGPIHMTNLG
500
TGFSSQNEIE
510
GAGSKPASSS
520
GKERERDRQL
530
MPPPAFPVTG
540
IKTESDERNG
550
SGTLTGSHDY
560
PAKKMKTTEK
570
GFGLVAYAAD
580
SSDEEEEHGG
590
HKNASSFPQG
600
WSLGYQYPSS
610
QPRAKQQMPF
WMAP
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0003723 | RNA binding |
| Biological Process | GO:0006376 | mRNA splice site recognition |
Reference
[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.
[2] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.