Search Results

Overview

Uniprot IDQ7Z7G8
Protein NameIntermembrane lipid transfer protein VPS13B
Gene NameVPS13B
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
1768 NKAAEISKQEQKKVD

Function

Mediates the transfer of lipids between membranes at organelle contact sites (By similarity). Binds phosphatidylinositol 3-phosphate (By similarity). Functions as a tethering factor in the slow endocytic recycling pathway, to assist traffic between early and recycling endosomes (PubMed:24334764, PubMed:30962439, PubMed:32375900). Involved in the transport of proacrosomal vesicles to the nuclear dense lamina (NDL) during spermatid development (By similarity). Plays a role in the assembly of the Golgi apparatus, possibly by mediating trafficking to the Golgi membrane (PubMed:21865173). Plays a role in the development of the nervous system, and may be required for neuron projection development (PubMed:25492866, PubMed:32560273). May also play a role during adipose tissue development (PubMed:26358774). Required for maintenance of the ocular lens (By similarity)

Protein Sequence

10 MLESYVTPIL 20 MSYVNRYIKN 30 LKPSDLQLSL 40 WGGDVVLSKL 50 ELKLDVLEQE 60 LKLPFTFLSG 70 HIHELRIHVP 80 WTKLGSEPVV 90 ITINTMECIL 100 KLKDGIQDDH 110 ESCGSNSTNR 120 STAESTKSSI 130 KPRRMQQAAP 140 TDPDLPPGYV 150 QSLIRRVVNN 160 VNIVINNLIL 170 KYVEDDIVLS 180 VNITSAECYT 190 VGELWDRAFM 200 DISATDLVLR 210 KVINFSDCTV 220 CLDKRNASGK 230 IEFYQDPLLY 240 KCSFRTRLHF 250 TYENLNSKMP 260 SVIKIHTLVE 270 SLKLSITDQQ 280 LPMFIRIMQL 290 GIALYYGEIG 300 NFKEGEIEDL 310 TCHNKDMLGN 320 ITGSEDETRI 330 DMQYPAQHKG 340 QELYSQQDEE 350 QPQGWVSWAW 360 SFVPAIVSYD 370 DGEEDFVGND 380 PASTMHQQKA 390 QTLKDPIVSI 400 GFYCTKATVT 410 FKLTEMQVES 420 SYYSPQKVKS 430 KEVLCWEQEG 440 TTVEALMMGE 450 PFFDCQIGFV 460 GCRAMCLKGI 470 MGVKDFEENM 480 NRSETEACFF 490 ICGDNLSTKG 500 FTYLTNSLFD 510 YRSPENNGTR 520 AEFILDSTHH 530 KETYTEIAGM 540 QRFGAFYMDY 550 LYTMENTSGK 560 GSTNQQDFSS 570 GKSEDLGTVQ 580 EKSTKSLVIG 590 PLDFRLDSSA 600 VHRILKMIVC 610 ALEHEYEPYS 620 RLKSDIKDEN 630 ETILNPEEVA 640 LLEEYIPTRH 650 TSVTLLKCTC 660 TISMAEFNLL 670 DHLLPVIMGE 680 KNSSNFMNTT 690 NFQSLRPLPS 700 IRILVDKINL 710 EHSVPMYAEQ 720 LVHVVSSLTQ 730 PSDNLLHYCY 740 VHCYLKIFGF 750 QAGLTSLDCS 760 GSYCLPVPVI 770 PSFSTALYGK 780 LLKLPTCWTK 790 RSQIAITEGI 800 FELPNLTIQA 810 TRAQTLLLQA 820 IYQSWSHLGN 830 VSSSAVIEAL 840 INEIFLSIGV 850 KSKNPLPTLE 860 GSIQNVELKY 870 CSTSLVKCAS 880 GTMGSIKICA 890 KAPVDSGKEK 900 LIPLLQGPSD 910 TKDLHSTKWL 920 NESRKPESLL 930 APDLMAFTIQ 940 VPQYIDYCHN 950 SGAVLLCSIQ 960 GLAVNIDPIL 970 YTWLIYQPQK 980 RTSRHMQQQP 990 VVAVPLVMPV 1000 CRRKEDEVSI 1010 GSAPLAKQQS 1020 YQASEYASSP 1030 VKTKTVTESR 1040 PLSVPVKAML 1050 NISESCRSPE 1060 ERMKEFIGIV 1070 WNAVKHLTLQ 1080 LEVQSCCVFI 1090 PNDSLPSPST 1100 IVSGDIPGTV 1110 RSWYHGQTSM 1120 PGTLVLCLPQ 1130 IKIISAGHKY 1140 MEPLQEIPFV 1150 IPRPILEEGD 1160 AFPWTISLHN 1170 FSIYTLLGKQ 1180 VTLCLVEPMG 1190 CTSTLAVTSQ 1200 KLLATGPDTR 1210 HSFVVCLHVD 1220 LESLEIKCSN 1230 PQVQLFYELT 1240 DIMNKVWNKI 1250 QKRGNLNLSP 1260 TSPETMAGPV 1270 PTSPVRSSIG 1280 TAPPDTSTCS 1290 PSADIGTTTE 1300 GDSIQAGEES 1310 PFSDSVTLEQ 1320 TTSNIGGTSG 1330 RVSLWMQWVL 1340 PKITIKLFAP 1350 DPENKGTEVC 1360 MVSELEDLSA 1370 SIDVQDVYTK 1380 VKCKIESFNI 1390 DHYRSSLGEE 1400 CWSLGQCGGV 1410 FLSCTDKLNR 1420 RTLLVRPISK 1430 QDPFSNCSGF 1440 FPSTTTKLLD 1450 GTHQQHGFLS 1460 LTYTKAVTKN 1470 VRHKLTSRNE 1480 RRSFHKLSEG 1490 LMDGSPHFLH 1500 EILLSAQAFD 1510 IVLYFPLLNA 1520 IASIFQAKLP 1530 KTQKEKRKSP 1540 GQPMRTHTLT 1550 SRNLPLIYVN 1560 TSVIRIFIPK 1570 TEEMQPTVEA 1580 NQAAKEDTVV 1590 LKIGSVAMAP 1600 QADNPLGRSV 1610 LRKDIYQRAL 1620 NLGILRDPGS 1630 EIEDRQYQID 1640 LQSINIGTAQ 1650 WHQLKPEKES 1660 VSGGVVTETE 1670 RNSQNPALEW 1680 NMASSIRRHQ 1690 ERRAILTPVL 1700 TDFSVRITGA 1710 PAVIFTKVVS 1720 PENLHTEEIL 1730 VCGHSLEVNI 1740 TTNLDFFLSV 1750 AQVQLLHQLI 1760 VANMTGLEPS 1770 NKAAEISKQE 1780 QKKVDIFDGG 1790 MAETSSRYSG 1800 AQDSGIGSDS 1810 VKIRIVQIEQ 1820 HSGASQHRIA 1830 RPSRQSSIVK 1840 NLNFIPFDIF 1850 ITASRISLMT 1860 YSCMALSKSK 1870 SQEQKNNEKT 1880 DKSSLNLPEV 1890 DSDVAKPNQA 1900 CISTVTAEDL 1910 LRSSISFPSG 1920 KKIGVLSLES 1930 LHASTRSSAR 1940 QALGITIVRQ 1950 PGRRGTGDLQ 1960 LEPFLYFIVS 1970 QPSLLLSCHH 1980 RKQRVEVSIF 1990 DAVLKGVASD 2000 YKCIDPGKTL 2010 PEALDYCTVW 2020 LQTVPGEIDS 2030 KSGIPPSFIT 2040 LQIKDFLNGP 2050 ADVNLDISKP 2060 LKANLSFTKL 2070 DQINLFLKKI 2080 KNAHSLAHSE 2090 ETSAMSNTMV 2100 NKDDLPVSKY 2110 YRGKLSKPKI 2120 HGDGVQKISA 2130 QENMWRAVSC 2140 FQKISVQTTQ 2150 IVISMETVPH 2160 TSKPCLLASL 2170 SNLNGSLSVK 2180 ATQKVPGIIL 2190 GSSFLLSIND 2200 FLLKTSLKER 2210 SRILIGPCCA 2220 TANLEAKWCK 2230 HSGNPGPEQS 2240 IPKISIDLRG 2250 GLLQVFWGQE 2260 HLNCLVLLHE 2270 LLNGYLNEEG 2280 NFEVQVSEPV 2290 PQMSSPVEKN 2300 QTFKSEQSSD 2310 DLRTGLFQYV 2320 QDAESLKLPG 2330 VYEVLFYNET 2340 EDCPGMMLWR 2350 YPEPRVLTLV 2360 RITPVPFNTT 2370 EDPDISTADL 2380 GDVLQVPCSL 2390 EYWDELQKVF 2400 VAFREFNLSE 2410 SKVCELQLPD 2420 INLVNDQKKL 2430 VSSDLWRIVL 2440 NSSQNGADDQ 2450 SSASESGSQS 2460 TCDPLVTPTA 2470 LAACTRVDSC 2480 FTPWFVPSLC 2490 VSFQFAHLEF 2500 HLCHHLDQLG 2510 TAAPQYLQPF 2520 VSDRNMPSEL 2530 EYMIVSFREP 2540 HMYLRQWNNG 2550 SVCQEIQFLA 2560 QADCKLLECR 2570 NVTMQSVVKP 2580 FSIFGQMAVS 2590 SDVVEKLLDC 2600 TVIVDSVFVN 2610 LGQHVVHSLN 2620 TAIQAWQQNK 2630 CPEVEELVFS 2640 HFVICNDTQE 2650 TLRFGQVDTD 2660 ENILLASLHS 2670 HQYSWRSHKS 2680 PQLLHICIEG 2690 WGNWRWSEPF 2700 SVDHAGTFIR 2710 TIQYRGRTAS 2720 LIIKVQQLNG 2730 VQKQIIICGR 2740 QIICSYLSQS 2750 IELKVVQHYI 2760 GQDGQAVVRE 2770 HFDCLTAKQK 2780 LPSYILENNE 2790 LTELCVKAKG 2800 DEDWSRDVCL 2810 ESKAPEYSIV 2820 IQVPSSNSSI 2830 IYVWCTVLTL 2840 EPNSQVQQRM 2850 IVFSPLFIMR 2860 SHLPDPIIIH 2870 LEKRSLGLSE 2880 TQIIPGKGQE 2890 KPLQNIEPDL 2900 VHHLTFQARE 2910 EYDPSDCAVP 2920 ISTSLIKQIA 2930 TKVHPGGTVN 2940 QILDEFYGPE 2950 KSLQPIWPYN 2960 KKDSDRNEQL 2970 SQWDSPMRVK 2980 LSIWKPYVRT 2990 LLIELLPWAL 3000 LINESKWDLW 3010 LFEGEKIVLQ 3020 VPAGKIIIPP 3030 NFQEAFQIGI 3040 YWANTNTVHK 3050 SVAIKLVHNL 3060 TSPKWKDGGN 3070 GEVVTLDEEA 3080 FVDTEIRLGA 3090 FPGHQKLCQF 3100 CISSMVQQGI 3110 QIIQIEDKTT 3120 IINNTPYQIF 3130 YKPQLSVCNP 3140 HSGKEYFRVP 3150 DSATFSICPG 3160 GEQPAMKSSS 3170 LPCWDLMPDI 3180 SQSVLDASLL 3190 QKQIMLGFSP 3200 APGADSSQCW 3210 SLPAIVRPEF 3220 PRQSVAVPLG 3230 NFRENGFCTR 3240 AIVLTYQEHL 3250 GVTYLTLSED 3260 PSPRVIIHNR 3270 CPVKMLIKEN 3280 IKDIPKFEVY 3290 CKKIPSECSI 3300 HHELYHQISS 3310 YPDCKTKDLL 3320 PSLLLRVEPL 3330 DEVTTEWSDA 3340 IDINSQGTQV 3350 VFLTGFGYVY 3360 VDVVHQCGTV 3370 FITVAPEGKA 3380 GPILTNTNRA 3390 PEKIVTFKMF 3400 ITQLSLAVFD 3410 DLTHHKASAE 3420 LLRLTLDNIF 3430 LCVAPGAGPL 3440 PGEEPVAALF 3450 ELYCVEICCG 3460 DLQLDNQLYN 3470 KSNFHFAVLV 3480 CQGEKAEPIQ 3490 CSKMQSLLIS 3500 NKELEEYKEK 3510 CFIKLCITLN 3520 EGKSILCDIN 3530 EFSFELKPAR 3540 LYVEDTFVYY 3550 IKTLFDTYLP 3560 NSRLAGHSTH 3570 LSGGKQVLPM 3580 QVTQHARALV 3590 NPVKLRKLVI 3600 QPVNLLVSIH 3610 ASLKLYIASD 3620 HTPLSFSVFE 3630 RGPIFTTARQ 3640 LVHALAMHYA 3650 AGALFRAGWV 3660 VGSLDILGSP 3670 ASLVRSIGNG 3680 VADFFRLPYE 3690 GLTRGPGAFV 3700 SGVSRGTTSF 3710 VKHISKGTLT 3720 SITNLATSLA 3730 RNMDRLSLDE 3740 EHYNRQEEWR 3750 RQLPESLGEG 3760 LRQGLSRLGI 3770 SLLGAIAGIV 3780 DQPMQNFQKT 3790 SEAQASAGHK 3800 AKGVISGVGK 3810 GIMGVFTKPI 3820 GGAAELVSQT 3830 GYGILHGAGL 3840 SQLPKQRHQP 3850 SDLHADQAPN 3860 SHVKYVWKML 3870 QSLGRPEVHM 3880 ALDVVLVRGS 3890 GQEHEGCLLL 3900 TSEVLFVVSV 3910 SEDTQQQAFP 3920 VTEIDCAQDS 3930 KQNNLLTVQL 3940 KQPRVACDVE 3950 VDGVRERLSE 3960 QQYNRLVDYI 3970 TKTSCHLAPS 3980 CSSMQIPCPV 3990 VAAEPPPSTV 4000 KTYHYLVDPH 4010 FAQVFLSKFT 4020 MVKNKALRKG FP

Gene Ontology

Classification GO ID Description
Cellular Component GO:0002080 acrosomal membrane
Cellular Component GO:0033106 cis-Golgi network membrane
Cellular Component GO:0031901 early endosome membrane
Cellular Component GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane
Cellular Component GO:0000139 Golgi membrane
Cellular Component GO:0005765 lysosomal membrane
Cellular Component GO:0055038 recycling endosome membrane
Cellular Component GO:0032588 trans-Golgi network membrane
Molecular Function GO:0032266 phosphatidylinositol-3-phosphate binding
Biological Process GO:0001675 acrosome assembly
Biological Process GO:0060612 adipose tissue development
Biological Process GO:0007417 central nervous system development
Biological Process GO:0007030 Golgi organization
Biological Process GO:0090168 Golgi reassembly
Biological Process GO:0006869 lipid transport
Biological Process GO:0036438 maintenance of lens transparency
Biological Process GO:0007399 nervous system development
Biological Process GO:0031175 neuron projection development
Biological Process GO:0032458 slow endocytic recycling
Biological Process GO:0016192 vesicle-mediated transport

Reference

PMID: N/A