Search Results

Overview

Uniprot ID	Q7Z7K2
Protein Name	Zinc finger protein 467
Gene Name	ZNF467
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
368	GLSFGWKKNLATHQC

Function

Transcription factor that promotes adipocyte differentiation and suppresses osteoblast differentiation in the bone marrow. Enhances the osteoclast-supporting ability of stromal cells. Binds with STAT3 the consensus sequence 5'-CTTCTGGGAAGA-3' of the acute phase response element (APRE). Transactivates several promoters including FOS, OSM and PPARG. Recruits a histone deacetylase complex (By similarity)

Protein Sequence

10 MRETLEALSS 20 LGFSVGQPEM 30 APQSEPREGS 40 HNAQEQMSSS 50 REERALGVCS 60 GHEAPTPEEG 70 AHTEQAEAPC 80 RGQACSAQKA 90 QPVGTCPGEE 100 WMIRKVKVED 110 EDQEAEEEVE 120 WPQHLSLLPS 130 PFPAPDLGHL 140 AAAYKLEPGA 150 PGALSGLALS 160 GWGPMPEKPY 170 GCGECERRFR 180 DQLTLRLHQR 190 LHRGEGPCAC 200 PDCGRSFTQR 210 AHMLLHQRSH 220 RGERPFPCSE 230 CDKRFSKKAH 240 LTRHLRTHTG 250 ERPYPCAECG 260 KRFSQKIHLG 270 SHQKTHTGER 280 PFPCTECEKR 290 FRKKTHLIRH 300 QRIHTGERPY 310 QCAQCARSFT 320 HKQHLVRHQR 330 VHQTAGPARP 340 SPDSSASPHS 350 TAPSPTPSFP 360 GPKPFACSDC 370 GLSFGWKKNL 380 ATHQCLHRSE 390 GRPFGCDECA 400 LGATVDAPAA 410 KPLASAPGGP 420 GCGPGSDPVV 430 PQRAPSGERS 440 FFCPDCGRGF 450 SHGQHLARHP 460 RVHTGERPFA 470 CTQCDRRFGS 480 RPNLVAHSRA 490 HSGARPFACA 500 QCGRRFSRKS 510 HLGRHQAVHT 520 GSRPHACAVC 530 ARSFSSKTNL 540 VRHQAIHTGS 550 RPFSCPQCGK 560 SFSRKTHLVR 570 HQLIHGEAAH 580 AAPDAALAAP 590 AWSAPPEVAP PPLFF

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005634	nucleus
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding
Molecular Function	GO:0008270	zinc ion binding
Biological Process	GO:0006351	DNA-templated transcription
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[3] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.