Search Results

Overview

Uniprot IDQ7Z7K6
Protein NameCentromere protein V
Gene NameCENPV
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
11 SRSSAAAKLRGQKRS
126 ETFQKRQKLTSEGAA
52 SASQAGSKSQAVEKP

Function

Required for distribution of pericentromeric heterochromatin in interphase nuclei and for centromere formation and organization, chromosome alignment and cytokinesis

Protein Sequence

10 MRRSRSSAAA 20 KLRGQKRSGA 30 SGASAAPAAS 40 AAAALAPSAT 50 RTRRSASQAG 60 SKSQAVEKPP 70 SEKPRLRRSS 80 PRAQEEGPGE 90 PPPPELALLP 100 PPPPPPPTPA 110 TPTSSASNLD 120 LGEQRERWET 130 FQKRQKLTSE 140 GAAKLLLDTF 150 EYQGLVKHTG 160 GCHCGAVRFE 170 VWASADLHIF 180 DCNCSICKKK 190 QNRHFIVPAS 200 RFKLLKGAEH 210 ITTYTFNTHK 220 AQHTFCKRCG 230 VQSFYTPRSN 240 PGGFGIAPHC 250 LDEGTVRSMV 260 TEEFNGSDWE 270 KAMKEHKTIK NMSKE

Gene Ontology

Classification GO ID Description
Cellular Component GO:0000776 kinetochore
Cellular Component GO:0015630 microtubule cytoskeleton
Cellular Component GO:0005815 microtubule organizing center
Cellular Component GO:0031965 nuclear membrane
Cellular Component GO:0005730 nucleolus
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:0005876 spindle microtubule
Cellular Component GO:0051233 spindle midzone
Molecular Function GO:0016846 carbon-sulfur lyase activity
Molecular Function GO:0046872 metal ion binding
Molecular Function GO:0008017 microtubule binding
Biological Process GO:0001667 ameboidal-type cell migration
Biological Process GO:0051301 cell division
Biological Process GO:0031508 pericentric heterochromatin formation
Biological Process GO:0032467 positive regulation of cytokinesis
Biological Process GO:0033044 regulation of chromosome organization

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[4] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[5] Bao Q, Wan N, He Z, Cao J, Yuan W et al.. Subcellular Proteomic Mapping of Lysine Lactylation.. J Am Soc Mass Spectrom 35(12):3221-3232. 2024 Dec 4. PMID: 39569522.

[6] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.