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Overview

Uniprot ID	Q7Z7L1
Protein Name	Schlafen family member 11
Gene Name	SLFN11
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
168	LEEGPFHKIHKGVYQ

Function

Inhibitor of DNA replication that promotes cell death in response to DNA damage (PubMed:22927417, PubMed:26658330, PubMed:29395061). Acts as a guardian of the genome by killing cells with defective replication (PubMed:29395061). Persistently blocks stressed replication forks by opening chromatin across replication initiation sites at stressed replication forks, possibly leading to unwind DNA ahead of the MCM helicase and block fork progression, ultimately leading to cell death (PubMed:29395061). Upon DNA damage, inhibits translation of ATR or ATM based on distinct codon usage without disrupting early DNA damage response signaling (PubMed:30374083). Antiviral restriction factor with manganese-dependent type II tRNA endoribonuclease (PubMed:36115853). A single tRNA molecule is bound and cleaved by the SLFN11 dimer (PubMed:36115853). Specifically abrogates the production of retroviruses such as human immunodeficiency virus 1 (HIV-1) by acting as a specific inhibitor of the synthesis of retroviruses encoded proteins in a codon-usage-dependent manner (PubMed:23000900). Impairs the replication of human cytomegalovirus (HCMV) and some Flaviviruses (PubMed:35105802, PubMed:36115853). Exploits the unique viral codon bias towards A/T nucleotides (PubMed:23000900). Also acts as an interferon (IFN)-induced antiviral protein which acts as an inhibitor of retrovirus protein synthesis (PubMed:23000900)

Protein Sequence

10 MEANQCPLVV 20 EPSYPDLVIN 30 VGEVTLGEEN 40 RKKLQKIQRD 50 QEKERVMRAA 60 CALLNSGGGV 70 IRMAKKVEHP 80 VEMGLDLEQS 90 LRELIQSSDL 100 QAFFETKQQG 110 RCFYIFVKSW 120 SSGPFPEDRS 130 VKPRLCSLSS 140 SLYRRSETSV 150 RSMDSREAFC 160 FLKTKRKPKI 170 LEEGPFHKIH 180 KGVYQELPNS 190 DPADPNSDPA 200 DLIFQKDYLE 210 YGEILPFPES 220 QLVEFKQFST 230 KHFQEYVKRT 240 IPEYVPAFAN 250 TGGGYLFIGV 260 DDKSREVLGC 270 AKENVDPDSL 280 RRKIEQAIYK 290 LPCVHFCQPQ 300 RPITFTLKIV 310 NVLKRGELYG 320 YACMIRVNPF 330 CCAVFSEAPN 340 SWIVEDKYVC 350 SLTTEKWVGM 360 MTDTDPDLLQ 370 LSEDFECQLS 380 LSSGPPLSRP 390 VYSKKGLEHK 400 KELQQLLFSV 410 PPGYLRYTPE 420 SLWRDLISEH 430 RGLEELINKQ 440 MQPFFRGILI 450 FSRSWAVDLN 460 LQEKPGVICD 470 ALLIAQNSTP 480 ILYTILREQD 490 AEGQDYCTRT 500 AFTLKQKLVN 510 MGGYTGKVCV 520 RAKVLCLSPE 530 SSAEALEAAV 540 SPMDYPASYS 550 LAGTQHMEAL 560 LQSLVIVLLG 570 FRSLLSDQLG 580 CEVLNLLTAQ 590 QYEIFSRSLR 600 KNRELFVHGL 610 PGSGKTIMAM 620 KIMEKIRNVF 630 HCEAHRILYV 640 CENQPLRNFI 650 SDRNICRAET 660 RKTFLRENFE 670 HIQHIVIDEA 680 QNFRTEDGDW 690 YGKAKSITRR 700 AKGGPGILWI 710 FLDYFQTSHL 720 DCSGLPPLSD 730 QYPREELTRI 740 VRNADPIAKY 750 LQKEMQVIRS 760 NPSFNIPTGC 770 LEVFPEAEWS 780 QGVQGTLRIK 790 KYLTVEQIMT 800 CVADTCRRFF 810 DRGYSPKDVA 820 VLVSTAKEVE 830 HYKYELLKAM 840 RKKRVVQLSD 850 ACDMLGDHIV 860 LDSVRRFSGL 870 ERSIVFGIHP 880 RTADPAILPN 890 VLICLASRAK 900 QHLYIFPWGG H

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0005654	nucleoplasm
Cellular Component	GO:0005634	nucleus
Cellular Component	GO:0090734	site of DNA damage
Molecular Function	GO:0005524	ATP binding
Molecular Function	GO:0016887	ATP hydrolysis activity
Molecular Function	GO:0003677	DNA binding
Molecular Function	GO:0004519	endonuclease activity
Molecular Function	GO:0004386	helicase activity
Molecular Function	GO:0000049	tRNA binding
Biological Process	GO:0006338	chromatin remodeling
Biological Process	GO:0051607	defense response to virus
Biological Process	GO:0006974	DNA damage response
Biological Process	GO:0002376	immune system process
Biological Process	GO:0008156	negative regulation of DNA replication
Biological Process	GO:2000134	negative regulation of G1/S transition of mitotic cell cycle
Biological Process	GO:0043111	replication fork arrest

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.