Search Results

Overview

Uniprot IDQ80TJ1
Protein NameCalcium-dependent secretion activator 1
Gene NameCadps
OrganismMus musculus

Kla Sites from experimental identification

Position Flanking peptide
866 AKIEENQKDAENVGR

Function

Calcium-binding protein involved in exocytosis of vesicles filled with neurotransmitters and neuropeptides. Probably acts upstream of fusion in the biogenesis or maintenance of mature secretory vesicles. Regulates catecholamine loading of DCVs. May specifically mediate the Ca(2+)-dependent exocytosis of large dense-core vesicles (DCVs) and other dense-core vesicles by acting as a PtdIns(4,5)P2-binding protein that acts at prefusion step following ATP-dependent priming and participates in DCVs-membrane fusion. However, it may also participate in small clear synaptic vesicles (SVs) exocytosis and it is unclear whether its function is related to Ca(2+) triggering (By similarity)

Protein Sequence

10 MLDPSSSEEE 20 SDEILEEERG 30 KDVLGSAASG 40 ARLSPSRTSE 50 GSAGSAGMGG 60 SGAGAGVGAG 70 GGGGSGASSG 80 GGAGGLQPSS 90 RAGGGRPSSP 100 SPSVVSEKEK 110 EELERLQKEE 120 EERKKRLQLY 130 VFVMRCIAYP 140 FNAKQPTDMA 150 RRQQKISKQQ 160 LQTVKDRFQA 170 FLNGETQIVA 180 DEAFMNAVQS 190 YYEVFLKSDR 200 VARMVQSGGC 210 SANDSREVFK 220 KHIEKRVRSL 230 PEIDGLSKET 240 VLSSWMAKFD 250 AIYRGEEDPR 260 KQQARMTASA 270 ASELILSKEQ 280 LYEMFQNILG 290 IKKFEHQLLY 300 NACQLDNPDE 310 QAAQIRRELD 320 GRLQMADQIA 330 RERKFPKFVS 340 KEMENMYIEE 350 LKSSVNLLMA 360 NLESMPVSKG 370 GEFKLQKLKR 380 SHNASIIDMG 390 EESENQLSKS 400 DVLLSFSLEV 410 VIMEVQGLKS 420 LAPNRIVYCT 430 MEVEGGEKLQ 440 TDQAEASKPT 450 WGTQGDFSTT 460 HALPAVKVKL 470 FTESTGVLAL 480 EDKELGRVIL 490 HPTPNSPKQS 500 EWHKMTVSKN 510 CPDQDLKIKL 520 AVRMDKPQNM 530 KHSGYLWTIG 540 KNVWKRWKKR 550 FFVLVQVSQY 560 TFAMCSYREK 570 KAEPQELLQL 580 DGYTVDYTDP 590 QPGLEGGRAF 600 FNAVKEGDTV 610 IFASDDEQDR 620 ILWVQAMYRA 630 TGQSHKPVPP 640 TQVQKLNAKG 650 GNVPQLDAPI 660 SQFSGLKDAD 670 RAQKHGMDEF 680 ISSNPCNFDH 690 ASLFEMVQRL 700 TLDHRLNDSY 710 SCLGWFSPGQ 720 VFVLDEYCAR 730 NGVRGCHRHL 740 CYLRDLLERA 750 ENGAMIDPTL 760 LHYSFAFCAS 770 HVHGNRPDGI 780 GTVTVEEKER 790 FEEIKERLRV 800 LLENQITHFR 810 YCFPFGRPEG 820 ALKATLSLLE 830 RVLMKDIVTP 840 VPQEEVKTVI 850 RKCLEQAALV 860 NYSRLSEYAK 870 IEENQKDAEN 880 VGRLITPAKK 890 LEDTIRLAEL 900 VIEVLQQNEE 910 HHAEPHVDKG 920 EAFAWWSDLM 930 VEHAETFLSL 940 FAVDMDAALE 950 VQPPDTWDSF 960 PLFQLLNDFL 970 RTDYNLCNGK 980 FHKHLQDLFA 990 PLVVRYVDLM 1000 ESSIAQSIHR 1010 GFERESWEPV 1020 KSLTSNLPNV 1030 NLPNVNLPKV 1040 PNLPVNIPLG 1050 IPQMPTFSAP 1060 SWMAAIYDAD 1070 NGSGTSEDLF 1080 WKLDALQTFI 1090 RDLHWPEEEF 1100 GKHLEQRLKL 1110 MASDMIESCV 1120 KRTRIAFEVK 1130 LQKTSRSTDF 1140 RVPQSICTMF 1150 NVMVDAKAQS 1160 TKLCSMEMGQ 1170 EHQYHSKIDE 1180 LIEETVKEMI 1190 TLLVAKFVTI 1200 LEGVLAKLSR 1210 YDEGTLFSSF 1220 LSFTVKAASK 1230 YVDVPKPGMD 1240 VADAYVTFVR 1250 HSQDVLRDKV 1260 NEEMYIERLF 1270 DQWYNSSMNI 1280 ICTWLTDRMD 1290 LQLHIYQLKT 1300 LIRMVKKTYR 1310 DFRLQGVLDS 1320 TLNSKTYETI 1330 RNRLTVEEAT 1340 ASVSEGGGLQ 1350 GISMKDSDEE DEEDD

Gene Ontology

Classification GO ID Description
Cellular Component GO:0031410 cytoplasmic vesicle
Cellular Component GO:0005829 cytosol
Cellular Component GO:0031045 dense core granule
Cellular Component GO:0098674 extrinsic component of neuronal dense core vesicle membrane
Cellular Component GO:0098978 glutamatergic synapse
Cellular Component GO:0098793 presynapse
Molecular Function GO:0005509 calcium ion binding
Molecular Function GO:0005546 phosphatidylinositol-4,5-bisphosphate binding
Molecular Function GO:0019901 protein kinase binding
Biological Process GO:0017156 calcium-ion regulated exocytosis
Biological Process GO:0050432 catecholamine secretion
Biological Process GO:0006887 exocytosis
Biological Process GO:0099011 neuronal dense core vesicle exocytosis
Biological Process GO:1905415 positive regulation of dense core granule exocytosis
Biological Process GO:0045921 positive regulation of exocytosis
Biological Process GO:0099525 presynaptic dense core vesicle exocytosis
Biological Process GO:0015031 protein transport
Biological Process GO:0016082 synaptic vesicle priming
Biological Process GO:0016050 vesicle organization

Reference

[1] Chang J, Wu W, Qian P, Lu Z, He X et al.. Multi-omics study on the effect of moderate-intensity exercise on protein lactylation in mouse muscle tissue.. Front Cell Dev Biol 12:1472338. 2024. PMID: 39935788.