Search Results
Overview
| Uniprot ID | Q80Y14 |
|---|---|
| Protein Name | Glutaredoxin-related protein 5, mitochondrial |
| Gene Name | Glrx5 |
| Organism | Mus musculus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 147 | RSALVDEKDQDSK** |
Function
Monothiol glutaredoxin involved in mitochondrial iron-sulfur (Fe/S) cluster transfer (PubMed:19442627). Receives 2Fe/2S clusters from scaffold protein ISCU and mediates their transfer to apoproteins, to the 4Fe/FS cluster biosynthesis machinery, or export from mitochondrion (By similarity). Required for normal regulation of hemoglobin synthesis by the iron-sulfur protein ACO1 (By similarity)
Protein Sequence
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0030425 | dendrite |
| Cellular Component | GO:1990229 | iron-sulfur cluster assembly complex |
| Cellular Component | GO:0005759 | mitochondrial matrix |
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:0043025 | neuronal cell body |
| Molecular Function | GO:0051537 | 2 iron, 2 sulfur cluster binding |
| Molecular Function | GO:0046872 | metal ion binding |
| Biological Process | GO:0044571 | [2Fe-2S] cluster assembly |
| Biological Process | GO:0030097 | hemopoiesis |
| Biological Process | GO:0051604 | protein maturation |
Reference
[1] Zhuo W, Zhang M, Tan J, Gao Y, Wang Y et al.. Lysine lactylation analysis of proteins in the heart of the Kawasaki disease mouse model.. Front Cell Dev Biol 13:1550220. 2025. PMID: 40114965.
[2] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.