Search Results
Overview
| Uniprot ID | Q864V5 |
|---|---|
| Protein Name | FUN14 domain-containing protein 2 |
| Gene Name | FUNDC2 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 170 | EEVVSFVKKNVLVTG |
Function
Binds directly and specifically 1,2-Diacyl-sn-glycero-3-phospho-(1'-myo-inositol-3',4',5'-bisphosphate) (PIP3) leading to the recruitment of PIP3 to mitochondria and may play a role in the regulation of the platelet activation via AKT/GSK3B/cGMP signaling pathways (By similarity). May act as transcription factor that regulates SREBP1 (isoform SREBP-1C) expression in order to modulate triglyceride (TG) homeostasis in hepatocytes (By similarity)
Protein Sequence
10
METSSPRAGS
20
QPAPTAARYF
30
ASCRAEPLRV
40
SSRDQLAEMA
50
AASQGNFEGN
60
FESLDLAELA
70
KKQPWWRKLF
80
GQESGPSAEK
90
YSVATQLLIG
100
GVTGWCTGFI
110
FQKVGKLAAT
120
AVGGGFFLLQ
130
LANHTGYIKV
140
DWQRVEKDMK
150
KAKEQLKIRK
160
SNQIPTEVKS
170
KAEEVVSFVK
180
KNVLVTGGFF
GGFLLGMAS
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005741 | mitochondrial outer membrane |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0005547 | phosphatidylinositol-3,4,5-trisphosphate binding |
| Biological Process | GO:0000422 | autophagy of mitochondrion |
| Biological Process | GO:0006351 | DNA-templated transcription |
| Biological Process | GO:0035356 | intracellular triglyceride homeostasis |
| Biological Process | GO:0010543 | regulation of platelet activation |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.