Search Results
Overview
| Uniprot ID | Q86SE8 |
|---|---|
| Protein Name | Nucleoplasmin-2 |
| Gene Name | NPM2 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 180 | ASVAKKKKLEKEEEE |
Function
Core histones chaperone involved in chromatin reprogramming, especially during fertilization and early embryonic development. Probably involved in sperm DNA decondensation during fertilization
Protein Sequence
10
MNLSSASSTE
20
EKAVTTVLWG
30
CELSQERRTW
40
TFRPQLEGKQ
50
SCRLLLHTIC
60
LGEKAKEEMH
70
RVEILPPANQ
80
EDKKMQPVTI
90
ASLQASVLPM
100
VSMVGVQLSP
110
PVTFQLRAGS
120
GPVFLSGQER
130
YEASDLTWEE
140
EEEEEGEEEE
150
EEEEDDEDED
160
ADISLEEQSP
170
VKQVKRLVPQ
180
KQASVAKKKK
190
LEKEEEEIRA
200
SVRDKSPVKK
210
AKATARAKKP
GFKK
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Molecular Function | GO:0003723 | RNA binding |
| Biological Process | GO:0001824 | blastocyst development |
| Biological Process | GO:0006338 | chromatin remodeling |
| Biological Process | GO:0009994 | oocyte differentiation |
| Biological Process | GO:0045740 | positive regulation of DNA replication |
| Biological Process | GO:0045836 | positive regulation of meiotic nuclear division |
| Biological Process | GO:0007096 | regulation of exit from mitosis |
| Biological Process | GO:0007338 | single fertilization |
| Cellular Component | GO:0000785 | chromatin |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005730 | nucleolus |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0003682 | chromatin binding |
| Molecular Function | GO:0019899 | enzyme binding |
| Molecular Function | GO:0042393 | histone binding |
| Molecular Function | GO:0042802 | identical protein binding |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.