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Overview

Uniprot IDQ86SQ0
Protein NamePleckstrin homology-like domain family B member 2
Gene NamePHLDB2
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
87 RSSPSLAKIQGSKQF

Function

Seems to be involved in the assembly of the postsynaptic apparatus. May play a role in acetyl-choline receptor (AChR) aggregation in the postsynaptic membrane (By similarity)

Protein Sequence

10 MEEHSYIQKE 20 LDLQNGSLEE 30 DSVVHSVEND 40 SQNMMESLSP 50 KKYSSSLRFK 60 ANGDYSGSYL 70 TLSQPVPAKR 80 SPSPLGTSVR 90 SSPSLAKIQG 100 SKQFSYDGTD 110 KNIPMKPPTP 120 LLNTTSSLSG 130 YPLGRADFDH 140 YTGRDSERAL 150 RLSEKPPYSK 160 YSSRHKSHDN 170 VYSLGGLEGR 180 KASGSLLAMW 190 NGSSLSDAGP 200 PPISRSGAAS 210 MPSSPKQARK 220 MSIQDSLALQ 230 PKLTRHKELA 240 SENINLRTRK 250 YSSSSLSHMG 260 AYSRSLPRLY 270 RATENQLTPL 280 SLPPRNSLGN 290 SKRTKLGEKD 300 LPHSVIDNDN 310 YLNFSSLSSG 320 ALPYKTSASE 330 GNPYVSSTLS 340 VPASPRVARK 350 MLLASTSSCA 360 SDDFDQASYV 370 GTNPSHSLLA 380 GESDRVFATR 390 RNFSCGSVEF 400 DEADLESLRQ 410 ASGTPQPALR 420 ERKSSISSIS 430 GRDDLMDYHR 440 RQREERLREQ 450 EMERLERQRL 460 ETILSLCAEY 470 TKPDSRLSTG 480 TTVEDVQKIN 490 KELEKLQLSD 500 EESVFEEALM 510 SPDTRYRCHR 520 KDSLPDADLA 530 SCGSLSQSSA 540 SFFTPRSTRN 550 DELLSDLTRT 560 PPPPSSTFPK 570 ASSESSYLSI 580 LPKTPEGISE 590 EQRSQELAAM 600 EETRIVILNN 610 LEELKQKIKD 620 INDQMDESFR 630 ELDMECALLD 640 GEQKSETTEL 650 MKEKEILDHL 660 NRKIAELEKN 670 IVGEKTKEKV 680 KLDAEREKLE 690 RLQELYSEQK 700 TQLDNCPESM 710 REQLQQQLKR 720 DADLLDVESK 730 HFEDLEFQQL 740 EHESRLDEEK 750 ENLTQQLLRE 760 VAEYQRNIVS 770 RKEKISALKK 780 QANHIVQQAQ 790 REQDHFVKEK 800 NNLIMMLQRE 810 KENLCNLEKK 820 YSSLSGGKGF 830 PVNPNTLKEG 840 YISVNEINEP 850 CGNSTNLSPS 860 TQFPADADAV 870 ATEPATAVLA 880 SQPQSKEHFR 890 SLEERKKQHK 900 EGLYLSDTLP 910 RKKTTSSISP 920 HFSSATMGRS 930 ITPKAHLPLG 940 QSNSCGSVLP 950 PSLAAMAKDS 960 ESRRMLRGYN 970 HQQMSEGHRQ 980 KSEFYNRTAS 990 ESNVYLNSFH 1000 YPDHSYKDQA 1010 FDTLSLDSSD 1020 SMETSISACS 1030 PDNISSASTS 1040 NIARIEEMER 1050 LLKQAHAEKT 1060 RLLESREREM 1070 EAKKRALEEE 1080 KRRREILEKR 1090 LQEETSQRQK 1100 LIEKEVKIRE 1110 RQRAQARPLT 1120 RYLPVRKEDF 1130 DLRSHVETAG 1140 HNIDTCYHVS 1150 ITEKTCRGFL 1160 IKMGGKIKTW 1170 KKRWFVFDRN 1180 KRTFSYYADK 1190 HETKLKGVIY 1200 FQAIEEVYYD 1210 HLKNANKSPN 1220 PLLTFSVKTH 1230 DRIYYMVAPS 1240 PEAMRIWMDV 1250 IVTGAEGYTH FLL

Gene Ontology

Classification GO ID Description
Cellular Component GO:0045180 basal cortex
Cellular Component GO:0005938 cell cortex
Cellular Component GO:0031252 cell leading edge
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005886 plasma membrane
Cellular Component GO:0002102 podosome
Molecular Function GO:0045296 cadherin binding
Biological Process GO:0071711 basement membrane organization
Biological Process GO:0016477 cell migration
Biological Process GO:0030010 establishment of cell polarity
Biological Process GO:0045184 establishment of protein localization
Biological Process GO:0000226 microtubule cytoskeleton organization
Biological Process GO:0051895 negative regulation of focal adhesion assembly
Biological Process GO:0051497 negative regulation of stress fiber assembly
Biological Process GO:1903690 negative regulation of wound healing, spreading of epidermal cells

Reference

[1] Cheng Z, Huang H, Li M, Chen Y. Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells.. iScience 27(1):108645. 2024 Jan 19. PMID: 38155775.

[2] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[3] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.