Search Results
Overview
| Uniprot ID | Q86SQ7 |
|---|---|
| Protein Name | Serologically defined colon cancer antigen 8 |
| Gene Name | SDCCAG8 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 542 | LHLTRQEKDSIQQSF |
Function
Plays a role in the establishment of cell polarity and epithelial lumen formation (By similarity). Also plays an essential role in ciliogenesis and subsequent Hedgehog signaling pathway that requires the presence of intact primary cilia for pathway activation. Mechanistically, interacts with and mediates RABEP2 centrosomal localization which is critical for ciliogenesis (PubMed:27224062)
Protein Sequence
10
MAKSPENSTL
20
EEILGQYQRS
30
LREHASRSIH
40
QLTCALKEGD
50
VTIGEDAPNL
60
SFSTSVGNED
70
ARTAWPELQQ
80
SHAVNQLKDL
90
LRQQADKESE
100
VSPSRRRKMS
110
PLRSLEHEET
120
NMPTMHDLVH
130
TINDQSQYIH
140
HLEAEVKFCK
150
EELSGMKNKI
160
QVVVLENEGL
170
QQQLKSQRQE
180
ETLREQTLLD
190
ASGNMHNSWI
200
TTGEDSGVGE
210
TSKRPFSHDN
220
ADFGKAASAG
230
EQLELEKLKL
240
TYEEKCEIEE
250
SQLKFLRNDL
260
AEYQRTCEDL
270
KEQLKHKEFL
280
LAANTCNRVG
290
GLCLKCAQHE
300
AVLSQTHTNV
310
HMQTIERLVK
320
ERDDLMSALV
330
SVRSSLADTQ
340
QREASAYEQV
350
KQVLQISEEA
360
NFEKTKALIQ
370
CDQLRKELER
380
QAERLEKELA
390
SQQEKRAIEK
400
DMMKKEITKE
410
REYMGSKMLI
420
LSQNIAQLEA
430
QVEKVTKEKI
440
SAINQLEEIQ
450
SQLASREMDV
460
TKVCGEMRYQ
470
LNKTNMEKDE
480
AEKEHREFRA
490
KTNRDLEIKD
500
QEIEKLRIEL
510
DESKQHLEQE
520
QQKAALAREE
530
CLRLTELLGE
540
SEHQLHLTRQ
550
EKDSIQQSFS
560
KEAKAQALQA
570
QQREQELTQK
580
IQQMEAQHDK
590
TENEQYLLLT
600
SQNTFLTKLK
610
EECCTLAKKL
620
EQISQKTRSE
630
IAQLSQEKRY
640
TYDKLGKLQR
650
RNEELEEQCV
660
QHGRVHETMK
670
QRLRQLDKHS
680
QATAQQLVQL
690
LSKQNQLLLE
700
RQSLSEEVDR
710
LRTQLPSMPQ
SDC
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005911 | cell-cell junction |
| Cellular Component | GO:0034451 | centriolar satellite |
| Cellular Component | GO:0005814 | centriole |
| Cellular Component | GO:0005813 | centrosome |
| Cellular Component | GO:0036064 | ciliary basal body |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0097733 | photoreceptor cell cilium |
| Biological Process | GO:0030030 | cell projection organization |
| Biological Process | GO:0007098 | centrosome cycle |
| Biological Process | GO:0030010 | establishment of cell polarity |
| Biological Process | GO:0031023 | microtubule organizing center organization |
| Biological Process | GO:0001764 | neuron migration |
| Biological Process | GO:1902017 | regulation of cilium assembly |
| Biological Process | GO:0035148 | tube formation |
Reference
[1] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.