Search Results
Overview
| Uniprot ID | Q86SX6 |
|---|---|
| Protein Name | Glutaredoxin-related protein 5, mitochondrial |
| Gene Name | GLRX5 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 151 | HSALLDEKKDQDSK* |
Function
Monothiol glutaredoxin involved in mitochondrial iron-sulfur (Fe/S) cluster transfer (PubMed:20364084, PubMed:23615440). Receives 2Fe/2S clusters from scaffold protein ISCU and mediates their transfer to apoproteins, to the 4Fe/FS cluster biosynthesis machinery, or export from mitochondrion (PubMed:20364084, PubMed:23615440, PubMed:24334290). Required for normal regulation of hemoglobin synthesis by the iron-sulfur protein ACO1 (PubMed:20364084)
Protein Sequence
10
MSGSLGRAAA
20
ALLRWGRGAG
30
GGGLWGPGVR
40
AAGSGAGGGG
50
SAEQLDALVK
60
KDKVVVFLKG
70
TPEQPQCGFS
80
NAVVQILRLH
90
GVRDYAAYNV
100
LDDPELRQGI
110
KDYSNWPTIP
120
QVYLNGEFVG
130
GCDILLQMHQ
140
NGDLVEELKK
150
LGIHSALLDE
KKDQDSK
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0030425 | dendrite |
| Cellular Component | GO:0005759 | mitochondrial matrix |
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:0043025 | neuronal cell body |
| Molecular Function | GO:0051537 | 2 iron, 2 sulfur cluster binding |
| Molecular Function | GO:0046872 | metal ion binding |
| Biological Process | GO:0044571 | [2Fe-2S] cluster assembly |
| Biological Process | GO:0045454 | cell redox homeostasis |
| Biological Process | GO:0030097 | hemopoiesis |
| Biological Process | GO:0006879 | intracellular iron ion homeostasis |
| Biological Process | GO:0016226 | iron-sulfur cluster assembly |
| Biological Process | GO:0051604 | protein maturation |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.