Overview
| Uniprot ID | Q86T24 |
|---|
| Protein Name | Transcriptional regulator Kaiso |
|---|
| Gene Name | ZBTB33 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 474 |
SGSEMANKRMKVKHD |
| 582 |
QDPSGDSKLYRLHPC |
Function
Transcriptional regulator with bimodal DNA-binding specificity. Binds to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' and also binds to the non-methylated consensus sequence 5'-CTGCNA-3' also known as the consensus kaiso binding site (KBS). Recruits the N-CoR repressor complex to promote histone deacetylation and the formation of repressive chromatin structures in target gene promoters. May contribute to the repression of target genes of the Wnt signaling pathway. May also activate transcription of a subset of target genes by the recruitment of CTNND2. Represses expression of MMP7 in conjunction with transcriptional corepressors CBFA2T3, CBFA2T2 and RUNX1T1 (PubMed:23251453)
Protein Sequence
10
MESRKLISAT
20
DIQYSGSLLN
30
SLNEQRGHGL
40
FCDVTVIVED
50
RKFRAHKNIL
60
SASSTYFHQL
70
FSVAGQVVEL
80
SFIRAEIFAE
90
ILNYIYSSKI
100
VRVRSDLLDE
110
LIKSGQLLGV
120
KFIAELGVPL
130
SQVKSISGTA
140
QDGNTEPLPP
150
DSGDKNLVIQ
160
KSKDEAQDNG
170
ATIMPIITES
180
FSLSAEDYEM
190
KKIIVTDSDD
200
DDDDVIFCSE
210
ILPTKETLPS
220
NNTVAQVQSN
230
PGPVAISDVA
240
PSASNNSPPL
250
TNITPTQKLP
260
TPVNQATLSQ
270
TQGSEKLLVS
280
SAPTHLTPNI
290
ILLNQTPLST
300
PPNVSSSLPN
310
HMPSSINLLV
320
QNQQTPNSAI
330
LTGNKANEEE
340
EEEIIDDDDD
350
TISSSPDSAV
360
SNTSLVPQAD
370
TSQNTSFDGS
380
LIQKMQIPTL
390
LQEPLSNSLK
400
ISDIITRNTN
410
DPGVGSKHLM
420
EGQKIITLDT
430
ATEIEGLSTG
440
CKVYANIGED
450
TYDIVIPVKD
460
DPDEGEARLE
470
NEIPKTSGSE
480
MANKRMKVKH
490
DDHYELIVDG
500
RVYYICIVCK
510
RSYVCLTSLR
520
RHFNIHSWEK
530
KYPCRYCEKV
540
FPLAEYRTKH
550
EIHHTGERRY
560
QCLACGKSFI
570
NYQFMSSHIK
580
SVHSQDPSGD
590
SKLYRLHPCR
600
SLQIRQYAYL
610
SDRSSTIPAM
620
KDDGIGYKVD
630
TGKEPPVGTT
640
TSTQNKPMTW
650
EDIFIQQEND
660
SIFKQNVTDG
670
STEFEFIIPE
SY
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0000785 |
chromatin |
| Biological Process |
GO:0002682 |
regulation of immune system process |
| Biological Process |
GO:0016055 |
Wnt signaling pathway |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0005654 |
nucleoplasm |
| Cellular Component |
GO:0005634 |
nucleus |
| Cellular Component |
GO:0005886 |
plasma membrane |
| Molecular Function |
GO:0000981 |
DNA-binding transcription factor activity, RNA polymerase II-specific |
| Molecular Function |
GO:0001227 |
DNA-binding transcription repressor activity, RNA polymerase II-specific |
| Molecular Function |
GO:0008327 |
methyl-CpG binding |
| Molecular Function |
GO:0000978 |
RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| Molecular Function |
GO:0043565 |
sequence-specific DNA binding |
| Molecular Function |
GO:1990837 |
sequence-specific double-stranded DNA binding |
| Molecular Function |
GO:0008270 |
zinc ion binding |
| Biological Process |
GO:0006351 |
DNA-templated transcription |
| Biological Process |
GO:0035556 |
intracellular signal transduction |
| Biological Process |
GO:0045892 |
negative regulation of DNA-templated transcription |
| Biological Process |
GO:0000122 |
negative regulation of transcription by RNA polymerase II |
| Biological Process |
GO:0001817 |
regulation of cytokine production |
Reference
[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.