Search Results

Overview

Uniprot IDQ86TB9
Protein NameProtein PAT1 homolog 1
Gene NamePATL1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
460 GPKKERTKLITPQVA
495 SSVNNPRKMIDAVVT
755 SRYVDRQKLNLLETK
762 KLNLLETKLQLVQGI

Function

RNA-binding protein involved in deadenylation-dependent decapping of mRNAs, leading to the degradation of mRNAs (PubMed:17936923, PubMed:20543818, PubMed:20584987, PubMed:20852261). Acts as a scaffold protein that connects deadenylation and decapping machinery (PubMed:17936923, PubMed:20543818, PubMed:20584987, PubMed:20852261). Required for cytoplasmic mRNA processing body (P-body) assembly (PubMed:17936923, PubMed:20543818, PubMed:20584987, PubMed:20852261)

Protein Sequence

10 MFRYESLEDC 20 PLDEDEDAFQ 30 GLGEEDEEID 40 QFNDDTFGSG 50 AVDDDWQEAH 60 ERLAELEEKL 70 PVAVNEQTGN 80 GERDEMDLLG 90 DHEENLAERL 100 SKMVIENELE 110 DPAIMRAVQT 120 RPVLQPQPGS 130 LNSSIWDGSE 140 VLRRIRGPLL 150 AQEMPTVSVL 160 EYALPQRPPQ 170 GPEDDRDLSE 180 RALPRRSTSP 190 IIGSPPVRAV 200 PIGTPPKQMA 210 VPSFTQQILC 220 PKPVHVRPPM 230 PPRYPAPYGE 240 RMSPNQLCSV 250 PNSSLLGHPF 260 PPSVPPVLSP 270 LQRAQLLGGA 280 QLQPGRMSPS 290 QFARVPGFVG 300 SPLAAMNPKL 310 LQGRVGQMLP 320 PAPGFRAFFS 330 APPSATPPPQ 340 QHPPGPGPHL 350 QNLRSQAPMF 360 RPDTTHLHPQ 370 HRRLLHQRQQ 380 QNRSQHRNLN 390 GAGDRGSHRS 400 SHQDHLRKDP 410 YANLMLQREK 420 DWVSKIQMMQ 430 LQSTDPYLDD 440 FYYQNYFEKL 450 EKLSAAEEIQ 460 GDGPKKERTK 470 LITPQVAKLE 480 HAYKPVQFEG 490 SLGKLTVSSV 500 NNPRKMIDAV 510 VTSRSEDDET 520 KEKQVRDKRR 530 KTLVIIEKTY 540 SLLLDVEDYE 550 RRYLLSLEEE 560 RPALMDDRKH 570 KICSMYDNLR 580 GKLPGQERPS 590 DDHFVQIMCI 600 RKGKRMVARI 610 LPFLSTEQAA 620 DILMTTARNL 630 PFLIKKDAQD 640 EVLPCLLSPF 650 SLLLYHLPSV 660 SITSLLRQLM 670 NLPQSAATPA 680 LSNPHLTAVL 690 QNKFGLSLLL 700 ILLSRGEDLQ 710 SSDPATESTQ 720 NNQWTEVMFM 730 ATRELLRIPQ 740 AALAKPISIP 750 TNLVSLFSRY 760 VDRQKLNLLE 770 TKLQLVQGIR

Gene Ontology

Classification GO ID Description
Cellular Component GO:0036464 cytoplasmic ribonucleoprotein granule
Cellular Component GO:0005829 cytosol
Cellular Component GO:0016607 nuclear speck
Cellular Component GO:0000932 P-body
Cellular Component GO:0016605 PML body
Molecular Function GO:0034046 poly(G) binding
Molecular Function GO:0008266 poly(U) RNA binding
Molecular Function GO:0003723 RNA binding
Biological Process GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA
Biological Process GO:0033962 P-body assembly

Reference

[1] Cheng Z, Huang H, Li M, Chen Y. Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells.. iScience 27(1):108645. 2024 Jan 19. PMID: 38155775.

[2] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[3] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.