Overview
| Uniprot ID | Q86TG7 |
|---|
| Protein Name | Retrotransposon-derived protein PEG10 |
|---|
| Gene Name | PEG10 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 22 |
NLREKVMKQSEENNN |
Function
Retrotransposon-derived protein that binds its own mRNA and self-assembles into virion-like capsids (PubMed:34413232). Forms virion-like extracellular vesicles that encapsulate their own mRNA and are released from cells, enabling intercellular transfer of PEG10 mRNA (PubMed:34413232). Binds its own mRNA in the 5'-UTR region, in the region near the boundary between the nucleocapsid (NC) and protease (PRO) coding sequences and in the beginning of the 3'-UTR region (PubMed:34413232). Involved in placenta formation: required for trophoblast stem cells differentiation (By similarity). Involved at the immediate early stage of adipocyte differentiation (By similarity). Overexpressed in many cancers and enhances tumor progression: promotes cell proliferation by driving cell cycle progression from G0/G1 (PubMed:12810624, PubMed:16423995, PubMed:26235627, PubMed:28193232). Enhances cancer progression by inhibiting the TGF-beta signaling, possibly via interaction with the TGF-beta receptor ACVRL1 (PubMed:15611116, PubMed:26235627, PubMed:30094509). May bind to the 5'-GCCTGTCTTT-3' DNA sequence of the MB1 domain in the myelin basic protein (MBP) promoter; additional evidences are however required to confirm this result (By similarity)
Protein Sequence
10
MTERRRDELS
20
EEINNLREKV
30
MKQSEENNNL
40
QSQVQKLTEE
50
NTTLREQVEP
60
TPEDEDDDIE
70
LRGAAAAAAP
80
PPPIEEECPE
90
DLPEKFDGNP
100
DMLAPFMAQC
110
QIFMEKSTRD
120
FSVDRVRVCF
130
VTSMMTGRAA
140
RWASAKLERS
150
HYLMHNYPAF
160
MMEMKHVFED
170
PQRREVAKRK
180
IRRLRQGMGS
190
VIDYSNAFQM
200
IAQDLDWNEP
210
ALIDQYHEGL
220
SDHIQEELSH
230
LEVAKSLSAL
240
IGQCIHIERR
250
LARAAAARKP
260
RSPPRALVLP
270
HIASHHQVDP
280
TEPVGGARMR
290
LTQEEKERRR
300
KLNLCLYCGT
310
GGHYADNCPA
320
KASKSSPAGK
330
LPGPAVEGPS
340
ATGPEIIRSP
350
QDDASSPHLQ
360
VMLQIHLPGR
370
HTLFVRAMID
380
SGASGNFIDH
390
EYVAQNGIPL
400
RIKDWPILVE
410
AIDGRPIASG
420
PVVHETHDLI
430
VDLGDHREVL
440
SFDVTQSPFF
450
PVVLGVRWLS
460
THDPNITWST
470
RSIVFDSEYC
480
RYHCRMYSPI
490
PPSLPPPAPQ
500
PPLYYPVDGY
510
RVYQPVRYYY
520
VQNVYTPVDE
530
HVYPDHRLVD
540
PHIEMIPGAH
550
SIPSGHVYSL
560
SEPEMAALRD
570
FVARNVKDGL
580
ITPTIAPNGA
590
QVLQVKRGWK
600
LQVSYDCRAP
610
NNFTIQNQYP
620
RLSIPNLEDQ
630
AHLATYTEFV
640
PQIPGYQTYP
650
TYAAYPTYPV
660
GFAWYPVGRD
670
GQGRSLYVPV
680
MITWNPHWYR
690
QPPVPQYPPP
700
QPPPPPPPPP
PPPSYSTL
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:1903561 |
extracellular vesicle |
| Cellular Component |
GO:0005634 |
nucleus |
| Molecular Function |
GO:0003677 |
DNA binding |
| Molecular Function |
GO:0003729 |
mRNA binding |
| Molecular Function |
GO:0003723 |
RNA binding |
| Molecular Function |
GO:0008270 |
zinc ion binding |
| Biological Process |
GO:0006915 |
apoptotic process |
| Biological Process |
GO:0030154 |
cell differentiation |
| Biological Process |
GO:0051028 |
mRNA transport |
| Biological Process |
GO:0030512 |
negative regulation of transforming growth factor beta receptor signaling pathway |
| Biological Process |
GO:0001890 |
placenta development |
| Biological Process |
GO:0051260 |
protein homooligomerization |
| Biological Process |
GO:0110077 |
vesicle-mediated intercellular transport |
| Biological Process |
GO:0075523 |
viral translational frameshifting |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.