Search Results
Overview
| Uniprot ID | Q86TU7 |
|---|---|
| Protein Name | Actin-histidine N-methyltransferase |
| Gene Name | SETD3 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 11 | KSRVKTQKSGTGATA |
Function
Protein-histidine N-methyltransferase that specifically mediates 3-methylhistidine (tele-methylhistidine) methylation of actin at 'His-73' (PubMed:30526847, PubMed:30626964, PubMed:30785395, PubMed:31388018, PubMed:31993215). Histidine methylation of actin is required for smooth muscle contraction of the laboring uterus during delivery (PubMed:30626964). Does not have protein-lysine N-methyltransferase activity and probably only catalyzes histidine methylation of actin (PubMed:30626964, PubMed:30785395, PubMed:31388018)
Protein Sequence
10
MGKKSRVKTQ
20
KSGTGATATV
30
SPKEILNLTS
40
ELLQKCSSPA
50
PGPGKEWEEY
60
VQIRTLVEKI
70
RKKQKGLSVT
80
FDGKREDYFP
90
DLMKWASENG
100
ASVEGFEMVN
110
FKEEGFGLRA
120
TRDIKAEELF
130
LWVPRKLLMT
140
VESAKNSVLG
150
PLYSQDRILQ
160
AMGNIALAFH
170
LLCERASPNS
180
FWQPYIQTLP
190
SEYDTPLYFE
200
EDEVRYLQST
210
QAIHDVFSQY
220
KNTARQYAYF
230
YKVIQTHPHA
240
NKLPLKDSFT
250
YEDYRWAVSS
260
VMTRQNQIPT
270
EDGSRVTLAL
280
IPLWDMCNHT
290
NGLITTGYNL
300
EDDRCECVAL
310
QDFRAGEQIY
320
IFYGTRSNAE
330
FVIHSGFFFD
340
NNSHDRVKIK
350
LGVSKSDRLY
360
AMKAEVLARA
370
GIPTSSVFAL
380
HFTEPPISAQ
390
LLAFLRVFCM
400
TEEELKEHLL
410
GDSAIDRIFT
420
LGNSEFPVSW
430
DNEVKLWTFL
440
EDRASLLLKT
450
YKTTIEEDKS
460
VLKNHDLSVR
470
AKMAIKLRLG
480
EKEILEKAVK
490
SAAVNREYYR
500
QQMEEKAPLP
510
KYEESNLGLL
520
ESSVGDSRLP
530
LVLRNLEEEA
540
GVQDALNIRE
550
AISKAKATEN
560
GLVNGENSIP
570
NGTRSENESL
580
NQESKRAVED
590
AKGSSSDSTA
GVKE
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0000785 | chromatin |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005654 | nucleoplasm |
| Molecular Function | GO:0003779 | actin binding |
| Molecular Function | GO:0046975 | histone H3K36 methyltransferase activity |
| Molecular Function | GO:0042800 | histone H3K4 methyltransferase activity |
| Molecular Function | GO:0018064 | protein-L-histidine N-tele-methyltransferase activity |
| Molecular Function | GO:0061629 | RNA polymerase II-specific DNA-binding transcription factor binding |
| Molecular Function | GO:0003713 | transcription coactivator activity |
| Biological Process | GO:0030047 | actin modification |
| Biological Process | GO:0018021 | peptidyl-histidine methylation |
| Biological Process | GO:0045893 | positive regulation of DNA-templated transcription |
| Biological Process | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| Biological Process | GO:0070472 | regulation of uterine smooth muscle contraction |
Reference
[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.