Search Results
Overview
| Uniprot ID | Q86TX2 |
|---|---|
| Protein Name | Acyl-coenzyme A thioesterase 1 |
| Gene Name | ACOT1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 268 | VGGTLRYKGETLPPV |
| 340 | FYANEACKRLQAHGR |
| 400 | MAQVDAWKQLQTFFH |
| 42 | RASLRDEKGALFQAH |
| 420 | HEGTIPSKV****** |
Function
Catalyzes the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating their respective intracellular levels. More active towards saturated and unsaturated long chain fatty acyl-CoAs (C12-C20)
Protein Sequence
10
MAATLILEPA
20
GRCCWDEPVR
30
IAVRGLAPEQ
40
PVTLRASLRD
50
EKGALFQAHA
60
RYRADTLGEL
70
DLERAPALGG
80
SFAGLEPMGL
90
LWALEPEKPL
100
VRLVKRDVRT
110
PLAVELEVLD
120
GHDPDPGRLL
130
CRVRHERYFL
140
PPGVRREPVR
150
AGRVRGTLFL
160
PPEPGPFPGI
170
VDMFGTGGGL
180
LEYRASLLAG
190
KGFAVMALAY
200
YNYEDLPKTM
210
ETLHLEYFEE
220
AVNYLLSHPE
230
VKGPGVGLLG
240
ISKGGELCLS
250
MASFLKGITA
260
AVVINGSVAN
270
VGGTLRYKGE
280
TLPPVGVNRN
290
RIKVTKDGYA
300
DIVDVLNSPL
310
EGPDQKSFIP
320
VERAESTFLF
330
LVGQDDHNWK
340
SEFYANEACK
350
RLQAHGRRKP
360
QIICYPETGH
370
YIEPPYFPLC
380
RASLHALVGS
390
PIIWGGEPRA
400
HAMAQVDAWK
410
QLQTFFHKHL
420
GGHEGTIPSK
V
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005739 | mitochondrion |
| Molecular Function | GO:0052689 | carboxylic ester hydrolase activity |
| Molecular Function | GO:0047617 | fatty acyl-CoA hydrolase activity |
| Biological Process | GO:0006637 | acyl-CoA metabolic process |
| Biological Process | GO:0006631 | fatty acid metabolic process |
| Biological Process | GO:0001676 | long-chain fatty acid metabolic process |
| Biological Process | GO:0000038 | very long-chain fatty acid metabolic process |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.