Search Results

Overview

Uniprot ID	Q86U86
Protein Name	Protein polybromo-1
Gene Name	PBRM1
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
317	LTGPSHSKGSLGEER

Function

Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Required for the stability of the SWI/SNF chromatin remodeling complex SWI/SNF-B (PBAF). Acts as a negative regulator of cell proliferation

Protein Sequence

10 MGSKRRRATS 20 PSSSVSGDFD 30 DGHHSVSTPG 40 PSRKRRRLSN 50 LPTVDPIAVC 60 HELYNTIRDY 70 KDEQGRLLCE 80 LFIRAPKRRN 90 QPDYYEVVSQ 100 PIDLMKIQQK 110 LKMEEYDDVN 120 LLTADFQLLF 130 NNAKSYYKPD 140 SPEYKAACKL 150 WDLYLRTRNE 160 FVQKGEADDE 170 DDDEDGQDNQ 180 GTVTEGSSPA 190 YLKEILEQLL 200 EAIVVATNPS 210 GRLISELFQK 220 LPSKVQYPDY 230 YAIIKEPIDL 240 KTIAQRIQNG 250 SYKSIHAMAK 260 DIDLLAKNAK 270 TYNEPGSQVF 280 KDANSIKKIF 290 YMKKAEIEHH 300 EMAKSSLRMR 310 TPSNLAAARL 320 TGPSHSKGSL 330 GEERNPTSKY 340 YRNKRAVQGG 350 RLSAITMALQ 360 YGSESEEDAA 370 LAAARYEEGE 380 SEAESITSFM 390 DVSNPFYQLY 400 DTVRSCRNNQ 410 GQLIAEPFYH 420 LPSKKKYPDY 430 YQQIKMPISL 440 QQIRTKLKNQ 450 EYETLDHLEC 460 DLNLMFENAK 470 RYNVPNSAIY 480 KRVLKLQQVM 490 QAKKKELARR 500 DDIEDGDSMI 510 SSATSDTGSA 520 KRKSKKNIRK 530 QRMKILFNVV 540 LEAREPGSGR 550 RLCDLFMVKP 560 SKKDYPDYYK 570 IILEPMDLKI 580 IEHNIRNDKY 590 AGEEGMIEDM 600 KLMFRNARHY 610 NEEGSQVYND 620 AHILEKLLKE 630 KRKELGPLPD 640 DDDMASPKLK 650 LSRKSGISPK 660 KSKYMTPMQQ 670 KLNEVYEAVK 680 NYTDKRGRRL 690 SAIFLRLPSR 700 SELPDYYLTI 710 KKPMDMEKIR 720 SHMMANKYQD 730 IDSMVEDFVM 740 MFNNACTYNE 750 PESLIYKDAL 760 VLHKVLLETR 770 RDLEGDEDSH 780 VPNVTLLIQE 790 LIHNLFVSVM 800 SHQDDEGRCY 810 SDSLAEIPAV 820 DPNFPNKPPL 830 TFDIIRKNVE 840 NNRYRRLDLF 850 QEHMFEVLER 860 ARRMNRTDSE 870 IYEDAVELQQ 880 FFIKIRDELC 890 KNGEILLSPA 900 LSYTTKHLHN 910 DVEKERKEKL 920 PKEIEEDKLK 930 REEEKREAEK 940 SEDSSGAAGL 950 SGLHRTYSQD 960 CSFKNSMYHV 970 GDYVYVEPAE 980 ANLQPHIVCI 990 ERLWEDSAGE 1000 KWLYGCWFYR 1010 PNETFHLATR 1020 KFLEKEVFKS 1030 DYYNKVPVSK 1040 ILGKCVVMFV 1050 KEYFKLCPEN 1060 FRDEDVFVCE 1070 SRYSAKTKSF 1080 KKIKLWTMPI 1090 SSVRFVPRDV 1100 PLPVVRVASV 1110 FANADKGDDE 1120 KNTDNSEDSR 1130 AEDNFNLEKE 1140 KEDVPVEMSN 1150 GEPGCHYFEQ 1160 LHYNDMWLKV 1170 GDCVFIKSHG 1180 LVRPRVGRIE 1190 KVWVRDGAAY 1200 FYGPIFIHPE 1210 ETEHEPTKMF 1220 YKKEVFLSNL 1230 EETCPMTCIL 1240 GKCAVLSFKD 1250 FLSCRPTEIP 1260 ENDILLCESR 1270 YNESDKQMKK 1280 FKGLKRFSLS 1290 AKVVDDEIYY 1300 FRKPIVPQKE 1310 PSPLLEKKIQ 1320 LLEAKFAELE 1330 GGDDDIEEMG 1340 EEDSEVIEPP 1350 SLPQLQTPLA 1360 SELDLMPYTP 1370 PQSTPKSAKG 1380 SAKKEGSKRK 1390 INMSGYILFS 1400 SEMRAVIKAQ 1410 HPDYSFGELS 1420 RLVGTEWRNL 1430 ETAKKAEYEE 1440 RAAKVAEQQE 1450 RERAAQQQQP 1460 SASPRAGTPV 1470 GALMGVVPPP 1480 TPMGMLNQQL 1490 TPVAGMMGGY 1500 PPGLPPLQGP 1510 VDGLVSMGSM 1520 QPLHPGGPPP 1530 HHLPPGVPGL 1540 PGIPPPGVMN 1550 QGVAPMVGTP 1560 APGGSPYGQQ 1570 VGVLGPPGQQ 1580 APPPYPGPHP 1590 AGPPVIQQPT 1600 TPMFVAPPPK 1610 TQRLLHSEAY 1620 LKYIEGLSAE 1630 SNSISKWDQT 1640 LAARRRDVHL 1650 SKEQESRLPS 1660 HWLKSKGAHT 1670 TMADALWRLR 1680 DLMLRDTLNI RQAYNLENV

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0000785	chromatin
Biological Process	GO:2000781	positive regulation of double-strand break repair
Biological Process	GO:0045663	positive regulation of myoblast differentiation
Biological Process	GO:0045582	positive regulation of T cell differentiation
Biological Process	GO:0070316	regulation of G0 to G1 transition
Biological Process	GO:2000045	regulation of G1/S transition of mitotic cell cycle
Biological Process	GO:0030071	regulation of mitotic metaphase/anaphase transition
Biological Process	GO:2000819	regulation of nucleotide-excision repair
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II
Biological Process	GO:0006368	transcription elongation by RNA polymerase II
Cellular Component	GO:0000776	kinetochore
Cellular Component	GO:0000228	nuclear chromosome
Cellular Component	GO:0016363	nuclear matrix
Cellular Component	GO:0005654	nucleoplasm
Cellular Component	GO:0005634	nucleus
Cellular Component	GO:0016586	RSC-type complex
Cellular Component	GO:0016514	SWI/SNF complex
Molecular Function	GO:0003682	chromatin binding
Molecular Function	GO:0003677	DNA binding
Biological Process	GO:0006338	chromatin remodeling
Biological Process	GO:0000278	mitotic cell cycle
Biological Process	GO:0008285	negative regulation of cell population proliferation
Biological Process	GO:0045597	positive regulation of cell differentiation

Reference

[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.