Search Results
Overview
| Uniprot ID | Q86UA6 |
|---|---|
| Protein Name | RPA-interacting protein |
| Gene Name | RPAIN |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 14 | SPRRSLYKLVGSPPW |
Function
Mediates the import of RPA complex into the nucleus, possibly via some interaction with importin beta. Isoform 2 is sumoylated and mediates the localization of RPA complex into the PML body of the nucleus, thereby participating in RPA function in DNA metabolism
Protein Sequence
10
MAESLRSPRR
20
SLYKLVGSPP
30
WKEAFRQRCL
40
ERMRNSRDRL
50
LNRYRQAGSS
60
GPGNSQNSFL
70
VQEVMEEEWN
80
ALQSVENCPE
90
DLAQLEELID
100
MAVLEEIQQE
110
LINQEQSIIS
120
EYEKSLQFDE
130
KCLSIMLAEW
140
EANPLICPVC
150
TKYNLRITSG
160
VVVCQCGLSI
170
PSHSSELTEQ
180
KLRACLEGSI
190
NEHSAHCPHT
200
PEFSVTGGTE
210
EKSSLLMSCL
ACDTWAVIL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0016605 | PML body |
| Molecular Function | GO:0008270 | zinc ion binding |
| Biological Process | GO:0006606 | protein import into nucleus |
| Biological Process | GO:0009411 | response to UV |
Reference
[1] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.
[2] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.