Search Results

Overview

Uniprot IDQ86UE4
Protein NameProtein LYRIC
Gene NameMTDH
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
174 KKSKSDAKAVQNSSR
195 DEGAWETKISHREKR
248 PVGSKKNKGDSHLNV
261 NVQVSNFKSGKGDST
292 GWNEKSVKLSSQISA
314 VSPASAGKRKTEPSA
316 PASAGKRKTEPSAWS
451 KKKKKKKKQGEDNST
479 DLPVNTSKTRPKQEK
483 NTSKTRPKQEKAFSL
486 KTRPKQEKAFSLKTI
491 QEKAFSLKTISTSDP
504 DPAEVLVKNSQPIKT
531 LSKSDSDKSSSQVPP

Function

Down-regulates SLC1A2/EAAT2 promoter activity when expressed ectopically. Activates the nuclear factor kappa-B (NF-kappa-B) transcription factor. Promotes anchorage-independent growth of immortalized melanocytes and astrocytes which is a key component in tumor cell expansion. Promotes lung metastasis and also has an effect on bone and brain metastasis, possibly by enhancing the seeding of tumor cells to the target organ endothelium. Induces chemoresistance

Protein Sequence

10 MAARSWQDEL 20 AQQAEEGSAR 30 LREMLSVGLG 40 FLRTELGLDL 50 GLEPKRYPGW 60 VILVGTGALG 70 LLLLFLLGYG 80 WAAACAGARK 90 KRRSPPRKRE 100 EAAAVPAAAP 110 DDLALLKNLR 120 SEEQKKKNRK 130 KLSEKPKPNG 140 RTVEVAEGEA 150 VRTPQSVTAK 160 QPPEIDKKNE 170 KSKKNKKKSK 180 SDAKAVQNSS 190 RHDGKEVDEG 200 AWETKISHRE 210 KRQQRKRDKV 220 LTDSGSLDST 230 IPGIENTITV 240 TTEQLTTASF 250 PVGSKKNKGD 260 SHLNVQVSNF 270 KSGKGDSTLQ 280 VSSGLNENLT 290 VNGGGWNEKS 300 VKLSSQISAG 310 EEKWNSVSPA 320 SAGKRKTEPS 330 AWSQDTGDAN 340 TNGKDWGRSW 350 SDRSIFSGIG 360 STAEPVSQST 370 TSDYQWDVSR 380 NQPYIDDEWS 390 GLNGLSSADP 400 NSDWNAPAEE 410 WGNWVDEERA 420 SLLKSQEPIP 430 DDQKVSDDDK 440 EKGEGALPTG 450 KSKKKKKKKK 460 KQGEDNSTAQ 470 DTEELEKEIR 480 EDLPVNTSKT 490 RPKQEKAFSL 500 KTISTSDPAE 510 VLVKNSQPIK 520 TLPPATSTEP 530 SVILSKSDSD 540 KSSSQVPPIL 550 QETDKSKSNT 560 KQNSVPPSQT 570 KSETSWESPK 580 QIKKKKKARR ET

Gene Ontology

Classification GO ID Description
Cellular Component GO:0016324 apical plasma membrane
Cellular Component GO:0005923 bicellular tight junction
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005783 endoplasmic reticulum
Cellular Component GO:0005789 endoplasmic reticulum membrane
Cellular Component GO:0046581 intercellular canaliculus
Cellular Component GO:0016604 nuclear body
Cellular Component GO:0031965 nuclear membrane
Cellular Component GO:0005730 nucleolus
Cellular Component GO:0005634 nucleus
Cellular Component GO:0048471 perinuclear region of cytoplasm
Molecular Function GO:0003725 double-stranded RNA binding
Molecular Function GO:0051059 NF-kappaB binding
Molecular Function GO:0003723 RNA binding
Molecular Function GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding
Molecular Function GO:0003713 transcription coactivator activity
Molecular Function GO:0003712 transcription coregulator activity
Biological Process GO:0031663 lipopolysaccharide-mediated signaling pathway
Biological Process GO:0043066 negative regulation of apoptotic process
Biological Process GO:0000122 negative regulation of transcription by RNA polymerase II
Biological Process GO:0045766 positive regulation of angiogenesis
Biological Process GO:0010508 positive regulation of autophagy
Biological Process GO:0043123 positive regulation of canonical NF-kappaB signal transduction
Biological Process GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
Biological Process GO:0006357 regulation of transcription by RNA polymerase II

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[3] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[4] Chao L, Xu Y, Yang Y, Ao X, Liang J. Identification of lactylation-related biomarkers for diagnosis, prognosis, and treatment responsiveness in triple-negative breast cancer.. World J Surg Oncol 24(1):77. 2026 Jan 22. PMID: 41566505.