Search Results

Overview

Uniprot IDQ86UP2
Protein NameKinectin
Gene NameKTN1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
1240 LLTELQKKLDDSYSE
1350 NQQLTKEKEHYQVLE
137 IKESDASKIPGKKVE
142 ASKIPGKKVEPVPVT
189 ETLMVPSKRQEALPL
324 DALKKSSKGELTTLI
345 DKLLAAVKEDAAATK
465 LVNELTEKTGKLQQE
477 QQEEVQKKNAEQAAT
543 LTDTLVSKQQLEQRL
678 MQQSVYVKDDKIRLL
711 NDQNKALKSEVQKLQ
777 TENSSLTKEVQDLKA
835 EKTVQDLKQEIKALK
842 KQEIKALKEEIGNVQ
886 MKAVLEEKEKDLANT
888 AVLEEKEKDLANTGK

Function

Receptor for kinesin thus involved in kinesin-driven vesicle motility. Accumulates in integrin-based adhesion complexes (IAC) upon integrin aggregation by fibronectin

Protein Sequence

10 MEFYESAYFI 20 VLIPSIVITV 30 IFLFFWLFMK 40 ETLYDEVLAK 50 QKREQKLIPT 60 KTDKKKAEKK 70 KNKKKEIQNG 80 NLHESDSESV 90 PRDFKLSDAL 100 AVEDDQVAPV 110 PLNVVETSSS 120 VRERKKKEKK 130 QKPVLEEQVI 140 KESDASKIPG 150 KKVEPVPVTK 160 QPTPPSEAAA 170 SKKKPGQKKS 180 KNGSDDQDKK 190 VETLMVPSKR 200 QEALPLHQET 210 KQESGSGKKK 220 ASSKKQKTEN 230 VFVDEPLIHA 240 TTYIPLMDNA 250 DSSPVVDKRE 260 VIDLLKPDQV 270 EGIQKSGTKK 280 LKTETDKENA 290 EVKFKDFLLS 300 LKTMMFSEDE 310 ALCVVDLLKE 320 KSGVIQDALK 330 KSSKGELTTL 340 IHQLQEKDKL 350 LAAVKEDAAA 360 TKDRCKQLTQ 370 EMMTEKERSN 380 VVITRMKDRI 390 GTLEKEHNVF 400 QNKIHVSYQE 410 TQQMQMKFQQ 420 VREQMEAEIA 430 HLKQENGILR 440 DAVSNTTNQL 450 ESKQSAELNK 460 LRQDYARLVN 470 ELTEKTGKLQ 480 QEEVQKKNAE 490 QAATQLKVQL 500 QEAERRWEEV 510 QSYIRKRTAE 520 HEAAQQDLQS 530 KFVAKENEVQ 540 SLHSKLTDTL 550 VSKQQLEQRL 560 MQLMESEQKR 570 VNKEESLQMQ 580 VQDILEQNEA 590 LKAQIQQFHS 600 QIAAQTSASV 610 LAEELHKVIA 620 EKDKQIKQTE 630 DSLASERDRL 640 TSKEEELKDI 650 QNMNFLLKAE 660 VQKLQALANE 670 QAAAAHELEK 680 MQQSVYVKDD 690 KIRLLEEQLQ 700 HEISNKMEEF 710 KILNDQNKAL 720 KSEVQKLQTL 730 VSEQPNKDVV 740 EQMEKCIQEK 750 DEKLKTVEEL 760 LETGLIQVAT 770 KEEELNAIRT 780 ENSSLTKEVQ 790 DLKAKQNDQV 800 SFASLVEELK 810 KVIHEKDGKI 820 KSVEELLEAE 830 LLKVANKEKT 840 VQDLKQEIKA 850 LKEEIGNVQL 860 EKAQQLSITS 870 KVQELQNLLK 880 GKEEQMNTMK 890 AVLEEKEKDL 900 ANTGKWLQDL 910 QEENESLKAH 920 VQEVAQHNLK 930 EASSASQFEE 940 LEIVLKEKEN 950 ELKRLEAMLK 960 ERESDLSSKT 970 QLLQDVQDEN 980 KLFKSQIEQL 990 KQQNYQQASS 1000 FPPHEELLKV 1010 ISEREKEISG 1020 LWNELDSLKD 1030 AVEHQRKKNN 1040 DLREKNWEAM 1050 EALASTEKML 1060 QDKVNKTSKE 1070 RQQQVEAVEL 1080 EAKEVLKKLF 1090 PKVSVPSNLS 1100 YGEWLHGFEK 1110 KAKECMAGTS 1120 GSEEVKVLEH 1130 KLKEADEMHT 1140 LLQLECEKYK 1150 SVLAETEGIL 1160 QKLQRSVEQE 1170 ENKWKVKVDE 1180 SHKTIKQMQS 1190 SFTSSEQELE 1200 RLRSENKDIE 1210 NLRREREHLE 1220 MELEKAEMER 1230 STYVTEVREL 1240 KDLLTELQKK 1250 LDDSYSEAVR 1260 QNEELNLLKA 1270 QLNETLTKLR 1280 TEQNERQKVA 1290 GDLHKAQQSL 1300 ELIQSKIVKA 1310 AGDTTVIENS 1320 DVSPETESSE 1330 KETMSVSLNQ 1340 TVTQLQQLLQ 1350 AVNQQLTKEK EHYQVLE

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005783 endoplasmic reticulum
Cellular Component GO:0005788 endoplasmic reticulum lumen
Cellular Component GO:0005789 endoplasmic reticulum membrane
Cellular Component GO:0016020 membrane
Cellular Component GO:0005886 plasma membrane
Molecular Function GO:0045296 cadherin binding
Molecular Function GO:0019894 kinesin binding
Molecular Function GO:0003723 RNA binding
Biological Process GO:0007018 microtubule-based movement
Biological Process GO:0015031 protein transport

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[3] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.