Search Results

Overview

Uniprot IDQ86UT6
Protein NameNLR family member X1
Gene NameNLRX1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
301 AIGRIPSKYVGRYGE

Function

Participates in antiviral signaling. Acts as a negative regulator of MAVS-mediated antiviral responses, through the inhibition of the virus-induced RLH (RIG-like helicase)-MAVS interaction (PubMed:18200010). Instead, promotes autophagy by interacting with TUFM and subsequently recruiting the autophagy-related proteins ATG5 and ATG12 (PubMed:22749352). Also regulates MAVS-dependent NLRP3 inflammasome activation to attenuate apoptosis (PubMed:27393910). Has no inhibitory function on NF-kappa-B signaling pathway, but enhances NF-kappa-B and JUN N-terminal kinase dependent signaling through the production of reactive oxygen species (PubMed:18219313). Regulates viral mediated-inflammation and energy metabolism in a sex-dependent manner (By similarity). In females, prevents uncontrolled inflammation and energy metabolism and thus, may contribute to the sex differences observed in infectious and inflammatory diseases (By similarity)

Protein Sequence

10 MRWGHHLPRA 20 SWGSGFRRAL 30 QRPDDRIPFL 40 IHWSWPLQGE 50 RPFGPPRAFI 60 RHHGSSVDSA 70 PPPGRHGRLF 80 PSASATEAIQ 90 RHRRNLAEWF 100 SRLPREERQF 110 GPTFALDTVH 120 VDPVIRESTP 130 DELLRPPAEL 140 ALEHQPPQAG 150 LPPLALSQLF 160 NPDACGRRVQ 170 TVVLYGTVGT 180 GKSTLVRKMV 190 LDWCYGRLPA 200 FELLIPFSCE 210 DLSSLGPAPA 220 SLCQLVAQRY 230 TPLKEVLPLM 240 AAAGSHLLFV 250 LHGLEHLNLD 260 FRLAGTGLCS 270 DPEEPQEPAA 280 IIVNLLRKYM 290 LPQASILVTT 300 RPSAIGRIPS 310 KYVGRYGEIC 320 GFSDTNLQKL 330 YFQLRLNQPY 340 CGYAVGGSGV 350 SATPAQRDHL 360 VQMLSRNLEG 370 HHQIAAACFL 380 PSYCWLVCAT 390 LHFLHAPTPA 400 GQTLTSIYTS 410 FLRLNFSGET 420 LDSTDPSNLS 430 LMAYAARTMG 440 KLAYEGVSSR 450 KTYFSEEDVC 460 GCLEAGIRTE 470 EEFQLLHIFR 480 RDALRFFLAP 490 CVEPGRAGTF 500 VFTVPAMQEY 510 LAALYIVLGL 520 RKTTLQKVGK 530 EVAELVGRVG 540 EDVSLVLGIM 550 AKLLPLRALP 560 LLFNLIKVVP 570 RVFGRMVGKS 580 REAVAQAMVL 590 EMFREEDYYN 600 DDVLDQMGAS 610 ILGVEGPRRH 620 PDEPPEDEVF 630 ELFPMFMGGL 640 LSAHNRAVLA 650 QLGCPIKNLD 660 ALENAQAIKK 670 KLGKLGRQVL 680 PPSELLDHLF 690 FHYEFQNQRF 700 SAEVLSSLRQ 710 LNLAGVRMTP 720 VKCTVVAAVL 730 GSGRHALDEV 740 NLASCQLDPA 750 GLRTLLPVFL 760 RARKLGLQLN 770 SLGPEACKDL 780 RDLLLHDQCQ 790 ITTLRLSNNP 800 LTAAGVAVLM 810 EGLAGNTSVT 820 HLSLLHTGLG 830 DEGLELLAAQ 840 LDRNRQLQEL 850 NVAYNGAGDT 860 AALALARAAR 870 EHPSLELLHL 880 YFNELSSEGR 890 QVLRDLGGAA 900 EGGARVVVSL 910 TEGTAVSEYW 920 SVILSEVQRN 930 LNSWDRARVQ 940 RHLELLLRDL 950 EDSRGATLNP 960 WRKAQLLRVE 970 GEVRALLEQL GSSGS

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005741 mitochondrial outer membrane
Cellular Component GO:0005739 mitochondrion
Molecular Function GO:0005524 ATP binding
Biological Process GO:0045087 innate immune response
Biological Process GO:0043124 negative regulation of canonical NF-kappaB signal transduction
Biological Process GO:0039536 negative regulation of RIG-I signaling pathway

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.