Search Results

Overview

Uniprot ID	Q86UU0
Protein Name	B-cell CLL/lymphoma 9-like protein
Gene Name	BCL9L
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
108	VPPFSSLKGKVKRDR
110	PFSSLKGKVKRDRSV
275	QQNVPRAKLDQAPKV
686	LRHQLLEKRSMGMQR
83	GAGNHGAKANQISPS

Function

Transcriptional regulator that acts as an activator. Promotes beta-catenin transcriptional activity. Plays a role in tumorigenesis. Enhances the neoplastic transforming activity of CTNNB1 (By similarity)

Protein Sequence

10 MRILANKTRL 20 PHPRRREAPG 30 SPPLSPRGHC 40 PPAPAKPMHP 50 ENKLTNHGKT 60 GNGGAQSQHQ 70 NVNQGPTCNV 80 GSKGVGAGNH 90 GAKANQISPS 100 NSSLKNPQAG 110 VPPFSSLKGK 120 VKRDRSVSVD 130 SGEQREAGTP 140 SLDSEAKEVA 150 PRSKRRCVLE 160 RKQPYSGDEW 170 CSGPDSEEDD 180 KPIGATHNCN 190 VADPAMAAPQ 200 LGPGQTTQLP 210 LSESSVPGAP 220 HGPPPGLRPD 230 APGGGGGGGG 240 VPGKPPSQFV 250 YVFTTHLANT 260 AAEAVLQGRA 270 DSILAYHQQN 280 VPRAKLDQAP 290 KVPPTPEPLP 300 LSTPSAGTPQ 310 SQPPPLPPPP 320 PPAPGSAPPA 330 LPPEGPPEDS 340 SQDLAPNSVG 350 AASTGGGTGG 360 THPNTPTATT 370 ANNPLPPGGD 380 PSSAPGPALL 390 GEAAAPGNGQ 400 RSLVGSEGLS 410 KEQLEHRERS 420 LQTLRDIERL 430 LLRSGETEPF 440 LKGPPGGAGE 450 GGPPAQAPPP 460 PQQPPTAPPS 470 GLKKYEEPLQ 480 SMISQTQSLG 490 GPPLEHEVPG 500 HPPGGDMGQQ 510 MNMMIQRLGQ 520 DSLTPEQVAW 530 RKLQEEYYEE 540 KRRKEEQIGL 550 HGSRPLQDMM 560 GMGGMMVRGP 570 PPPYHSKPGD 580 QWPPGMGAQL 590 RGPMDVQDPM 600 QLRGGPPFPG 610 PRFPGNQIQR 620 VPGFGGMQSM 630 PMEVPMNAMQ 640 RPVRPGMGWT 650 EDLPPMGGPS 660 NFAQNTMPYP 670 GGQGEAERFM 680 TPRVREELLR 690 HQLLEKRSMG 700 MQRPLGMAGS 710 GMGQSMEMER 720 MMQAHRQMDP 730 AMFPGQMAGG 740 EGLAGTPMGM 750 EFGGGRGLLS 760 PPMGQSGLRE 770 VDPPMGPGNL 780 NMNMNVNMNM 790 NMNLNVQMTP 800 QQQMLMSQKM 810 RGPGDLMGPQ 820 GLSPEEMARV 830 RAQNSSGVMG 840 GPQKMLMPSQ 850 FPNQGQQGFS 860 GGQGPYQAMS 870 QDMGNTQDMF 880 SPDQSSMPMS 890 NVGTTRLSHM 900 PLPPASNPPG 910 TVHSAPNRGL 920 GRRPSDLTIS 930 INQMGSPGMG 940 HLKSPTLSQV 950 HSPLVTSPSA 960 NLKSPQTPSQ 970 MVPLPSANPP 980 GPLKSPQVLG 990 SSLSVRSPTG 1000 SPSRLKSPSM 1010 AVPSPGWVAS 1020 PKTAMPSPGV 1030 SQNKQPPLNM 1040 NSSTTLSNME 1050 QGTLPPSGPR 1060 SSSSAPPANP 1070 PSGLMNPSLP 1080 FTSSPDPTPS 1090 QNPLSLMMTQ 1100 MSKYAMPSST 1110 PLYHNAIKTI 1120 ATSDDELLPD 1130 RPLLPPPPPP 1140 QGSGPGISNS 1150 QPSQMHLNSA 1160 AAQSPMGMNL 1170 PGQQPLSHEP 1180 PPAMLPSPTP 1190 LGSNIPLHPN 1200 AQGTGGPPQN 1210 SMMMAPGGPD 1220 SLNAPCGPVP 1230 SSSQMMPFPP 1240 RLQQPHGAMA 1250 PTGGGGGGPG 1260 LQQHYPSGMA 1270 LPPEDLPNQP 1280 PGPMPPQQHL 1290 MGKAMAGRMG 1300 DAYPPGVLPG 1310 VASVLNDPEL 1320 SEVIRPTPTG 1330 IPEFDLSRII 1340 PSEKPSSTLQ 1350 YFPKSENQPP 1360 KAQPPNLHLM 1370 NLQNMMAEQT 1380 PSRPPNLPGQ 1390 QGVQRGLNMS 1400 MCHPGQMSLL 1410 GRTGVPPQQG 1420 MVPHGLHQGV 1430 MSPPQGLMTQ 1440 QNFMLMKQRG 1450 VGGEVYSQPP 1460 HMLSPQGSLM 1470 GPPPQQNLMV 1480 SHPLRQRSVS 1490 LDSQMGYLPA PGGMANLPF

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:1990907	beta-catenin-TCF complex
Cellular Component	GO:0001650	fibrillar center
Cellular Component	GO:0005654	nucleoplasm
Cellular Component	GO:0005634	nucleus
Molecular Function	GO:0008013	beta-catenin binding
Molecular Function	GO:0003713	transcription coactivator activity
Biological Process	GO:0060070	canonical Wnt signaling pathway
Biological Process	GO:0006351	DNA-templated transcription
Biological Process	GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway
Biological Process	GO:0010718	positive regulation of epithelial to mesenchymal transition
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II
Biological Process	GO:0022604	regulation of cell morphogenesis

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[3] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[4] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.