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Overview

Uniprot IDQ86V21
Protein NameAcetoacetyl-CoA synthetase
Gene NameAACS
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
633 IPYTLNGKKVEVAVK
634 PYTLNGKKVEVAVKQ

Function

Converts acetoacetate to acetoacetyl-CoA in the cytosol (By similarity). Ketone body-utilizing enzyme, responsible for the synthesis of cholesterol and fatty acids (By similarity)

Protein Sequence

10 MSKEERPGRE 20 EILECQVMWE 30 PDSKKNTQMD 40 RFRAAVGAAC 50 GLALESYDDL 60 YHWSVESYSD 70 FWAEFWKFSG 80 IVFSRVYDEV 90 VDTSKGIADV 100 PEWFKGSRLN 110 YAENLLRHKE 120 NDRVALYIAR 130 EGKEEIVKVT 140 FEELRQEVAL 150 FAAAMRKMGV 160 KKGDRVVGYL 170 PNSEHAVEAM 180 LAAASIGAIW 190 SSTSPDFGVN 200 GVLDRFSQIQ 210 PKLIFSVEAV 220 VYNGKEHNHM 230 EKLQQVVKGL 240 PDLKKVVVIP 250 YVSSRENIDL 260 SKIPNSVFLD 270 DFLATGTSEQ 280 APQLEFEQLP 290 FSHPLFIMFS 300 SGTTGAPKCM 310 VHSAGGTLIQ 320 HLKEHLLHGN 330 MTSSDILLCY 340 TTVGWMMWNW 350 MVSLLATGAA 360 MVLYDGSPLV 370 PTPNVLWDLV 380 DRIGITVLVT 390 GAKWLSVLEE 400 KAMKPVETHS 410 LQMLHTILST 420 GSPLKAQSYE 430 YVYRCIKSSI 440 LLGSISGGTD 450 IISCFMGHNF 460 SLPVYKGEIQ 470 ARNLGMAVEA 480 WNEEGKAVWG 490 ESGELVCTKP 500 IPCQPTHFWN 510 DENGNKYRKA 520 YFSKFPGIWA 530 HGDYCRINPK 540 TGGIVMLGRS 550 DGTLNPNGVR 560 FGSSEIYNIV 570 ESFEEVEDSL 580 CVPQYNKYRE 590 ERVILFLKMA 600 SGHAFQPDLV 610 KRIRDAIRMG 620 LSARHVPSLI 630 LETKGIPYTL 640 NGKKVEVAVK 650 QIIAGKAVEQ 660 GGAFSNPETL 670 DLYRDIPELQ GF

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005829 cytosol
Molecular Function GO:0030729 acetoacetate-CoA ligase activity
Molecular Function GO:0005524 ATP binding
Biological Process GO:0006631 fatty acid metabolic process
Biological Process GO:0046951 ketone body biosynthetic process
Biological Process GO:0032024 positive regulation of insulin secretion

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Cheng Z, Huang H, Li M, Chen Y. Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells.. iScience 27(1):108645. 2024 Jan 19. PMID: 38155775.

[3] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.

[4] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.

[5] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.