Overview
| Uniprot ID | Q86V48 |
|---|
| Protein Name | Leucine zipper protein 1 |
|---|
| Gene Name | LUZP1 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 541 |
SSETVFGKRGHVLGN |
| 604 |
SKAPVLSKYPYSCRS |
Function
F-actin cross-linking protein (PubMed:30990684). Stabilizes actin and acts as a negative regulator of primary cilium formation (PubMed:32496561). Positively regulates the phosphorylation of both myosin II and protein phosphatase 1 regulatory subunit PPP1R12A/MYPT1 and promotes the assembly of myosin II stacks within actin stress fibers (PubMed:38832964). Inhibits the phosphorylation of myosin light chain MYL9 by DAPK3 and suppresses the constriction velocity of the contractile ring during cytokinesis (PubMed:38009294). Binds to microtubules and promotes epithelial cell apical constriction by up-regulating levels of diphosphorylated myosin light chain (MLC) through microtubule-dependent inhibition of MLC dephosphorylation by myosin phosphatase (By similarity). Involved in regulation of cell migration, nuclear size and centriole number, probably through regulation of the actin cytoskeleton (By similarity). Component of the CERF-1 and CERF-5 chromatin remodeling complexes in embryonic stem cells where it acts to stabilize the complexes (By similarity). Plays a role in embryonic brain and cardiovascular development (By similarity)
Protein Sequence
10
MAEFTSYKET
20
ASSRHLRFKL
30
QSLSRRLDEL
40
EEATKNLQKA
50
EDELLDLQDK
60
VIQAEGSNSS
70
MLAEIEVLRQ
80
RVLRIEGKDE
90
EIKRAEDLCR
100
LMKEKLEEEE
110
NLTRELKSEI
120
ERLQKRMAEL
130
EKLEEAFSRS
140
KNDCTQLCLS
150
LNEERNLTKK
160
ISSELEMLRV
170
KVKELESSED
180
RLDKTEQSLA
190
SELEKLKSLT
200
LSFVSERKYL
210
NEKEKENEKL
220
IKELTQKLEQ
230
NKKMNRDYTR
240
NASNLERNDL
250
RIEDGISSTL
260
PSKESRRKGG
270
LDYLKQVENE
280
TRNKSENEKN
290
RNQEDNKVKD
300
LNQEIEKLKT
310
QIKHFESLEE
320
ELKKMKSKNN
330
DLQDNYLSEQ
340
NKNKLLASQL
350
EEIKLQIKKQ
360
KELENGEVEG
370
EDAFLSSKGR
380
HERTKFRGHG
390
SEASVSKHTA
400
RELSPQHKRE
410
RLRNREFALN
420
NENYSLSNRQ
430
VSSPSFTNRR
440
AAKASHMGVS
450
TDSGTQETKK
460
TEDRFVPGSS
470
QSEGKKSREQ
480
PSVLSRYPPA
490
AQEHSKAWKG
500
TSKPGTESGL
510
KGKVEKTTRT
520
FSDTTHGSVP
530
SDPLGRADKA
540
SDTSSETVFG
550
KRGHVLGNGS
560
QVTQAANSGC
570
SKAIGALASS
580
RRSSSEGLSK
590
GKKAANGLEA
600
DNSCPNSKAP
610
VLSKYPYSCR
620
SQENILQGFS
630
TSHKEGVNQP
640
AAVVMEDSSP
650
HEALRCRVIK
660
SSGREKPDSD
670
DDLDIASLVT
680
AKLVNTTITP
690
EPEPKPQPNS
700
REKAKTRGAP
710
RTSLFENDKD
720
AGMENESVKS
730
VRASTNTMEL
740
PDTNGAGVKS
750
QRPFSPREAL
760
RSRAIIKPVI
770
VDKDVKKIMG
780
GSGTETTLEK
790
QKPVSKPGPN
800
KVTSSITIYP
810
SDSSSPRAAP
820
GEALRERHTS
830
TSNIQVGLAE
840
LTSVSNHVSS
850
PFELSIHKHD
860
ITLQLAEAER
870
MADGPLKDRP
880
ETVVSRSSII
890
IKPSDPVERN
900
SHAPPAETIR
910
WKSHSAPSEV
920
GFSDARHVTV
930
RNAWKSRRDL
940
KSLEDPPTRI
950
GKNVESTNSN
960
AYTQRSSTDF
970
SELEQPRSCL
980
FEQGTRRVGP
990
SSGDAPEPSS
1000
RRTQSSLTVS
1010
EVLTRRNRVG
1020
DTITVAAWNH
1030
SASMEEEGED
1040
CTLSVYRQLH
1050
NSLDPSELPG
1060
KQGLPESGRV
1070
RAEERLRPTR
PCAEEN
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0015629 |
actin cytoskeleton |
| Cellular Component |
GO:0005884 |
actin filament |
| Cellular Component |
GO:0005923 |
bicellular tight junction |
| Cellular Component |
GO:0005813 |
centrosome |
| Cellular Component |
GO:0090537 |
CERF complex |
| Cellular Component |
GO:0000775 |
chromosome, centromeric region |
| Cellular Component |
GO:0036064 |
ciliary basal body |
| Cellular Component |
GO:0030425 |
dendrite |
| Cellular Component |
GO:0070062 |
extracellular exosome |
| Cellular Component |
GO:0016020 |
membrane |
| Cellular Component |
GO:0005874 |
microtubule |
| Cellular Component |
GO:0030496 |
midbody |
| Cellular Component |
GO:0043204 |
perikaryon |
| Cellular Component |
GO:0051233 |
spindle midzone |
| Cellular Component |
GO:0001725 |
stress fiber |
| Cellular Component |
GO:0070160 |
tight junction |
| Molecular Function |
GO:0051015 |
actin filament binding |
| Molecular Function |
GO:0008017 |
microtubule binding |
| Biological Process |
GO:0003383 |
apical constriction |
| Biological Process |
GO:0036213 |
contractile ring contraction |
| Biological Process |
GO:1902018 |
negative regulation of cilium assembly |
| Biological Process |
GO:1903119 |
protein localization to actin cytoskeleton |
| Biological Process |
GO:0061635 |
regulation of protein complex stability |
| Biological Process |
GO:0043149 |
stress fiber assembly |
Reference
[1] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.