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Overview

Uniprot ID	Q86VB7
Protein Name	Scavenger receptor cysteine-rich type 1 protein M130
Gene Name	CD163
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
346	EPAIWQCKHHEWGKH

Function

Acute phase-regulated receptor involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner. Exhibits a higher affinity for complexes of hemoglobin and multimeric haptoglobin of HP*1F phenotype than for complexes of hemoglobin and dimeric haptoglobin of HP*1S phenotype. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1. Isoform 3 exhibits the higher capacity for ligand endocytosis and the more pronounced surface expression when expressed in cells

Protein Sequence

10 MSKLRMVLLE 20 DSGSADFRRH 30 FVNLSPFTIT 40 VVLLLSACFV 50 TSSLGGTDKE 60 LRLVDGENKC 70 SGRVEVKVQE 80 EWGTVCNNGW 90 SMEAVSVICN 100 QLGCPTAIKA 110 PGWANSSAGS 120 GRIWMDHVSC 130 RGNESALWDC 140 KHDGWGKHSN 150 CTHQQDAGVT 160 CSDGSNLEMR 170 LTRGGNMCSG 180 RIEIKFQGRW 190 GTVCDDNFNI 200 DHASVICRQL 210 ECGSAVSFSG 220 SSNFGEGSGP 230 IWFDDLICNG 240 NESALWNCKH 250 QGWGKHNCDH 260 AEDAGVICSK 270 GADLSLRLVD 280 GVTECSGRLE 290 VRFQGEWGTI 300 CDDGWDSYDA 310 AVACKQLGCP 320 TAVTAIGRVN 330 ASKGFGHIWL 340 DSVSCQGHEP 350 AIWQCKHHEW 360 GKHYCNHNED 370 AGVTCSDGSD 380 LELRLRGGGS 390 RCAGTVEVEI 400 QRLLGKVCDR 410 GWGLKEADVV 420 CRQLGCGSAL 430 KTSYQVYSKI 440 QATNTWLFLS 450 SCNGNETSLW 460 DCKNWQWGGL 470 TCDHYEEAKI 480 TCSAHREPRL 490 VGGDIPCSGR 500 VEVKHGDTWG 510 SICDSDFSLE 520 AASVLCRELQ 530 CGTVVSILGG 540 AHFGEGNGQI 550 WAEEFQCEGH 560 ESHLSLCPVA 570 PRPEGTCSHS 580 RDVGVVCSRY 590 TEIRLVNGKT 600 PCEGRVELKT 610 LGAWGSLCNS 620 HWDIEDAHVL 630 CQQLKCGVAL 640 STPGGARFGK 650 GNGQIWRHMF 660 HCTGTEQHMG 670 DCPVTALGAS 680 LCPSEQVASV 690 ICSGNQSQTL 700 SSCNSSSLGP 710 TRPTIPEESA 720 VACIESGQLR 730 LVNGGGRCAG 740 RVEIYHEGSW 750 GTICDDSWDL 760 SDAHVVCRQL 770 GCGEAINATG 780 SAHFGEGTGP 790 IWLDEMKCNG 800 KESRIWQCHS 810 HGWGQQNCRH 820 KEDAGVICSE 830 FMSLRLTSEA 840 SREACAGRLE 850 VFYNGAWGTV 860 GKSSMSETTV 870 GVVCRQLGCA 880 DKGKINPASL 890 DKAMSIPMWV 900 DNVQCPKGPD 910 TLWQCPSSPW 920 EKRLASPSEE 930 TWITCDNKIR 940 LQEGPTSCSG 950 RVEIWHGGSW 960 GTVCDDSWDL 970 DDAQVVCQQL 980 GCGPALKAFK 990 EAEFGQGTGP 1000 IWLNEVKCKG 1010 NESSLWDCPA 1020 RRWGHSECGH 1030 KEDAAVNCTD 1040 ISVQKTPQKA 1050 TTGRSSRQSS 1060 FIAVGILGVV 1070 LLAIFVALFF 1080 LTKKRRQRQR 1090 LAVSSRGENL 1100 VHQIQYREMN 1110 SCLNADDLDL 1120 MNSSENSHES 1130 ADFSAAELIS 1140 VSKFLPISGM 1150 EKEAILSHTE KENGNL

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0030666	endocytic vesicle membrane
Cellular Component	GO:0009897	external side of plasma membrane
Cellular Component	GO:0005576	extracellular region
Cellular Component	GO:0005886	plasma membrane
Molecular Function	GO:0097110	scaffold protein binding
Molecular Function	GO:0005044	scavenger receptor activity
Biological Process	GO:0006953	acute-phase response

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.