Overview
| Uniprot ID | Q86VP1 |
|---|
| Protein Name | Tax1-binding protein 1 |
|---|
| Gene Name | TAX1BP1 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 571 |
LKWKEQVKIAENVKL |
Function
Ubiquitin-binding adapter that participates in inflammatory, antiviral and innate immune processes as well as selective autophagy regulation (PubMed:29940186, PubMed:30459273, PubMed:30909570). Plays a key role in the negative regulation of NF-kappa-B and IRF3 signalings by acting as an adapter for the ubiquitin-editing enzyme A20/TNFAIP3 to bind and inactivate its substrates (PubMed:17703191). Disrupts the interactions between the E3 ubiquitin ligase TRAF3 and TBK1/IKBKE to attenuate 'Lys63'-linked polyubiquitination of TBK1 and thereby IFN-beta production (PubMed:21885437). Also recruits A20/TNFAIP3 to ubiquitinated signaling proteins TRAF6 and RIPK1, leading to their deubiquitination and disruption of IL-1 and TNF-induced NF-kappa-B signaling pathways (PubMed:17703191). Inhibits virus-induced apoptosis by inducing the 'Lys-48'-linked polyubiquitination and degradation of MAVS via recruitment of the E3 ligase ITCH, thereby attenuating MAVS-mediated apoptosis signaling (PubMed:27736772). As a macroautophagy/autophagy receptor, facilitates the xenophagic clearance of pathogenic bacteria such as Salmonella typhimurium and Mycobacterium tuberculosis (PubMed:26451915). Upon NBR1 recruitment to the SQSTM1-ubiquitin condensates, acts as the major recruiter of RB1CC1 to these ubiquitin condensates to promote their autophagic degradation (PubMed:33226137, PubMed:34471133). Mediates the autophagic degradation of other substrates including TICAM1 (PubMed:28898289)
Protein Sequence
10
MTSFQEVPLQ
20
TSNFAHVIFQ
30
NVAKSYLPNA
40
HLECHYTLTP
50
YIHPHPKDWV
60
GIFKVGWSTA
70
RDYYTFLWSP
80
MPEHYVEGST
90
VNCVLAFQGY
100
YLPNDDGEFY
110
QFCYVTHKGE
120
IRGASTPFQF
130
RASSPVEELL
140
TMEDEGNSDM
150
LVVTTKAGLL
160
ELKIEKTMKE
170
KEELLKLIAV
180
LEKETAQLRE
190
QVGRMERELN
200
HEKERCDQLQ
210
AEQKGLTEVT
220
QSLKMENEEF
230
KKRFSDATSK
240
AHQLEEDIVS
250
VTHKAIEKET
260
ELDSLKDKLK
270
KAQHEREQLE
280
CQLKTEKDEK
290
ELYKVHLKNT
300
EIENTKLMSE
310
VQTLKNLDGN
320
KESVITHFKE
330
EIGRLQLCLA
340
EKENLQRTFL
350
LTTSSKEDTC
360
FLKEQLRKAE
370
EQVQATRQEV
380
VFLAKELSDA
390
VNVRDRTMAD
400
LHTARLENEK
410
VKKQLADAVA
420
ELKLNAMKKD
430
QDKTDTLEHE
440
LRREVEDLKL
450
RLQMAADHYK
460
EKFKECQRLQ
470
KQINKLSDQS
480
ANNNNVFTKK
490
TGNQQKVNDA
500
SVNTDPATSA
510
STVDVKPSPS
520
AAEADFDIVT
530
KGQVCEMTKE
540
IADKTEKYNK
550
CKQLLQDEKA
560
KCNKYADELA
570
KMELKWKEQV
580
KIAENVKLEL
590
AEVQDNYKEL
600
KRSLENPAER
610
KMEGQNSQSP
620
QCFKTCSEQN
630
GYVLTLSNAQ
640
PVLQYGNPYA
650
SQETRDGADG
660
AFYPDEIQRP
670
PVRVPSWGLE
680
DNVVCSQPAR
690
NFSRPDGLED
700
SEDSKEDENV
710
PTAPDPPSQH
720
LRGHGTGFCF
730
DSSFDVHKKC
740
PLCELMFPPN
750
YDQSKFEEHV
760
ESHWKVCPMC
770
SEQFPPDYDQ
780
QVFERHVQTH
FDQNVLNFD
Gene Ontology
| Classification |
GO ID |
Description |
| Biological Process |
GO:0045087 |
innate immune response |
| Cellular Component |
GO:0005776 |
autophagosome |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0031410 |
cytoplasmic vesicle |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0070062 |
extracellular exosome |
| Cellular Component |
GO:0005739 |
mitochondrion |
| Cellular Component |
GO:0000407 |
phagophore assembly site |
| Molecular Function |
GO:0019900 |
kinase binding |
| Molecular Function |
GO:0030674 |
protein-macromolecule adaptor activity |
| Molecular Function |
GO:0035591 |
signaling adaptor activity |
| Molecular Function |
GO:0008270 |
zinc ion binding |
| Biological Process |
GO:0006915 |
apoptotic process |
| Biological Process |
GO:0006914 |
autophagy |
| Biological Process |
GO:0043066 |
negative regulation of apoptotic process |
| Biological Process |
GO:0043124 |
negative regulation of canonical NF-kappaB signal transduction |
| Biological Process |
GO:0039532 |
negative regulation of cytoplasmic pattern recognition receptor signaling pathway |
| Biological Process |
GO:2000660 |
negative regulation of interleukin-1-mediated signaling pathway |
| Biological Process |
GO:0034144 |
negative regulation of toll-like receptor 4 signaling pathway |
| Biological Process |
GO:0010804 |
negative regulation of tumor necrosis factor-mediated signaling pathway |
| Biological Process |
GO:1905161 |
protein localization to phagocytic vesicle |
Reference
[1] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.