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Overview

Uniprot IDQ86VQ3
Protein NameThioredoxin domain-containing protein 2
Gene NameTXNDC2
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
160 SAKPIQPKLGNIPKA
205 SEEAIQPKEGDIPKS
265 SAKPIQPKLGNIPKA

Function

Probably plays a regulatory role in sperm development. May participate in regulation of fibrous sheath (FS) assembly by supporting the formation of disulfide bonds during sperm tail morphogenesis. May also be required to rectify incorrect disulfide pairing and generate suitable pairs between the FS constituents. Can reduce disulfide bonds in vitro in the presence of NADP and thioredoxin reductase

Protein Sequence

10 MDVDKELGME 20 SVKAGASGKP 30 EMRLGTQEET 40 SEGDANESSL 50 LVLSSNVPLL 60 ALEFLEIAQA 70 KEKAFLPMVS 80 HTFHMRTEES 90 DASQEGDDLP 100 KSSANTSHPK 110 QDDSPKSSEE 120 TIQPKEGDIP 130 KAPEETIQSK 140 KEDLPKSSEK 150 AIQPKESNIP 160 KSSAKPIQPK 170 LGNIPKASVK 180 PSQPKEGDIP 190 KAPEETIQSK 200 KEDLPKSSEE 210 AIQPKEGDIP 220 KSSAKPIQPK 230 LGNIAKTSVK 240 PSQPKESDIP 250 KSPEETIQPK 260 EGDIPKSSAK 270 PIQPKLGNIP 280 KASVKPSQPK 290 EGDISKSPEE 300 AIQPKEGDLP 310 KSLEEAIQPK 320 EGDIPKSPEE 330 AIQPKEGDIP 340 KSLEEAIQPK 350 EGDIPKSPEE 360 TIQPKKGDIP 370 KSPEEAIQPK 380 EGDIPKSPKQ 390 AIQPKEGDIP 400 KSLEEAIPPK 410 EIDIPKSPEE 420 TIQPKEDDSP 430 KSLEEATPSK 440 EGDILKPEEE 450 TMEFPEGDKV 460 KVILSKEDFE 470 ASLKEAGERL 480 VAVDFSATWC 490 GPCRTIRPFF 500 HALSVKHEDV 510 VFLEVDADNC 520 EEVVRECAIM 530 CVPTFQFYKK 540 EEKVDELCGA 550 LKEKLEAVIA ELK

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Molecular Function GO:0004791 thioredoxin-disulfide reductase (NADPH) activity
Biological Process GO:0030154 cell differentiation
Biological Process GO:0045454 cell redox homeostasis
Biological Process GO:0007283 spermatogenesis

Reference

[1] Cheng Z, Huang H, Li M, Chen Y. Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells.. iScience 27(1):108645. 2024 Jan 19. PMID: 38155775.

[2] Yan M, Tu H, Tang S, Gai Z, Shi Q et al.. Lactylated Proteomic Analysis Reveals Functional Implications of Lysine Lactylation In Asthenozoospermia.. Mol Cell Proteomics 24(12):101439. 2025 Dec. PMID: 41192556.