Search Results

Overview

Uniprot IDQ86VS8
Protein NameProtein Hook homolog 3
Gene NameHOOK3
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
402 EYKRLKEKVDSLQKE
621 VIRTLDPKQNQGAAP

Function

Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track). Predominantly recruits 2 dyneins, which increases both the force and speed of the microtubule motor (PubMed:25035494, PubMed:33734450). Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). May regulate clearance of endocytosed receptors such as MSR1. Participates in defining the architecture and localization of the Golgi complex. FHF complex promotes the distribution of AP-4 complex to the perinuclear area of the cell (PubMed:32073997)

Protein Sequence

10 MFSVESLERA 20 ELCESLLTWI 30 QTFNVDAPCQ 40 TVEDLTNGVV 50 MAQVLQKIDP 60 AYFDENWLNR 70 IKTEVGDNWR 80 LKISNLKKIL 90 KGILDYNHEI 100 LGQQINDFTL 110 PDVNLIGEHS 120 DAAELGRMLQ 130 LILGCAVNCE 140 QKQEYIQAIM 150 MMEESVQHVV 160 MTAIQELMSK 170 ESPVSAGNDA 180 YVDLDRQLKK 190 TTEELNEALS 200 AKEEIAQRCH 210 ELDMQVAALQ 220 EEKSSLLAEN 230 QVLMERLNQS 240 DSIEDPNSPA 250 GRRHLQLQTQ 260 LEQLQEETFR 270 LEAAKDDYRI 280 RCEELEKEIS 290 ELRQQNDELT 300 TLADEAQSLK 310 DEIDVLRHSS 320 DKVSKLEGQV 330 ESYKKKLEDL 340 GDLRRQVKLL 350 EEKNTMYMQN 360 TVSLEEELRK 370 ANAARSQLET 380 YKRQVVELQN 390 RLSEESKKAD 400 KLDFEYKRLK 410 EKVDSLQKEK 420 DRLRTERDSL 430 KETIEELRCV 440 QAQEGQLTTQ 450 GLMPLGSQES 460 SDSLAAEIVT 470 PEIREKLIRL 480 QHENKMLKLN 490 QEGSDNEKIA 500 LLQSLLDDAN 510 LRKNELETEN 520 RLVNQRLLEV 530 QSQVEELQKS 540 LQDQGSKAED 550 SVLLKKKLEE 560 HLEKLHEANN 570 ELQKKRAIIE 580 DLEPRFNNSS 590 LKIEELQEAL 600 RKKEEEMKQM 610 EERYKKYLEK 620 AKSVIRTLDP 630 KQNQGAAPEI 640 QALKNQLQER 650 DRLFHSLEKE 660 YEKTKSQREM 670 EEKYIVSAWY 680 NMGMTLHKKA 690 AEDRLASTGS 700 GQSFLARQRQ 710 ATSSRRSYPG HVQPATAR

Gene Ontology

Classification GO ID Description
Cellular Component GO:0034451 centriolar satellite
Cellular Component GO:0005813 centrosome
Cellular Component GO:0005801 cis-Golgi network
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0070695 FHF complex
Cellular Component GO:0005794 Golgi apparatus
Cellular Component GO:0005874 microtubule
Cellular Component GO:0000242 pericentriolar material
Molecular Function GO:0034452 dynactin binding
Molecular Function GO:0045505 dynein intermediate chain binding
Molecular Function GO:0045503 dynein light chain binding
Molecular Function GO:0051959 dynein light intermediate chain binding
Molecular Function GO:0042802 identical protein binding
Molecular Function GO:0008017 microtubule binding
Biological Process GO:0031122 cytoplasmic microtubule organization
Biological Process GO:0030705 cytoskeleton-dependent intracellular transport
Biological Process GO:0045022 early endosome to late endosome transport
Biological Process GO:0007032 endosome organization
Biological Process GO:0008333 endosome to lysosome transport
Biological Process GO:0051645 Golgi localization
Biological Process GO:0022027 interkinetic nuclear migration
Biological Process GO:0007040 lysosome organization
Biological Process GO:0034454 microtubule anchoring at centrosome
Biological Process GO:0050768 negative regulation of neurogenesis
Biological Process GO:0071539 protein localization to centrosome
Biological Process GO:1905719 protein localization to perinuclear region of cytoplasm
Biological Process GO:0098840 protein transport along microtubule

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.