Search Results
Overview
| Uniprot ID | Q86VY4 |
|---|---|
| Protein Name | Testis-specific Y-encoded-like protein 5 |
| Gene Name | TSPYL5 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 108 | AARPGPGKAASLSER |
Function
Involved in modulation of cell growth and cellular response to gamma radiation probably via regulation of the Akt signaling pathway. Involved in regulation of p53/TP53. Suppresses p53/TP53 protein levels and promotes its ubiquitination; the function is dependent on USP7 and independent on MDM2. Proposed to displace p53/TP53 from interaction with USP7
Protein Sequence
10
MSGRSRGRKS
20
SRAKNRGKGR
30
AKARVRPAPD
40
DAPRDPDPSQ
50
YQSLGEDTQA
60
AQVQAGAGWG
70
GLEAAASAQL
80
LRLGEEAACR
90
LPLDCGLALR
100
ARAAGDHGQA
110
AARPGPGKAA
120
SLSERLAADT
130
VFVGTAGTVG
140
RPKNAPRVGN
150
RRGPAGKKAP
160
ETCSTAGRGP
170
QVIAGGRQKK
180
GAAGENTSVS
190
AGEEKKEERD
200
AGSGPPATEG
210
SMDTLENVQL
220
KLENMNAQAD
230
RAYLRLSRKF
240
GQLRLQHLER
250
RNHLIQNIPG
260
FWGQAFQNHP
270
QLASFLNSQE
280
KEVLSYLNSL
290
EVEELGLARL
300
GYKIKFYFDR
310
NPYFQNKVLI
320
KEYGCGPSGQ
330
VVSRSTPIQW
340
LPGHDLQSLS
350
QGNPENNRSF
360
FGWFSNHSSI
370
ESDKIVEIIN
380
EELWPNPLQF
390
YLLSEGARVE
400
KGKEKEGRQG
410
PGKQPMETTQ
PGVSQSN
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Biological Process | GO:0031398 | positive regulation of protein ubiquitination |
| Cellular Component | GO:0000785 | chromatin |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0003682 | chromatin binding |
| Molecular Function | GO:0042393 | histone binding |
| Biological Process | GO:0071480 | cellular response to gamma radiation |
| Biological Process | GO:0006334 | nucleosome assembly |
| Biological Process | GO:0008284 | positive regulation of cell population proliferation |
| Biological Process | GO:0051897 | positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction |
| Biological Process | GO:0051260 | protein homooligomerization |
Reference
[1] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.