Search Results

Overview

Uniprot ID	Q86W26
Protein Name	NACHT, LRR and PYD domains-containing protein 10
Gene Name	NLRP10
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
185	GKTTLARKMVLDWAT
532	SFSNLELKFCFRISP

Function

Inhibits autoprocessing of CASP1, CASP1-dependent IL1B secretion, PYCARD aggregation and PYCARD-mediated apoptosis but not apoptosis induced by FAS or BID (PubMed:15096476). Displays anti-inflammatory activity (PubMed:20393137). Required for immunity against C.albicans infection (By similarity). Involved in the innate immune response by contributing to pro-inflammatory cytokine release in response to invasive bacterial infection (PubMed:22672233). Contributes to T-cell-mediated inflammatory responses in the skin (By similarity). Plays a role in protection against periodontitis through its involvement in induction of IL1A via ERK activation in oral epithelial cells infected with periodontal pathogens (PubMed:28766990). Exhibits both ATPase and GTPase activities (PubMed:23861819)

Protein Sequence

10 MAMAKARKPR 20 EALLWALSDL 30 EENDFKKLKF 40 YLRDMTLSEG 50 QPPLARGELE 60 GLIPVDLAEL 70 LISKYGEKEA 80 VKVVLKGLKV 90 MNLLELVDQL 100 SHICLHDYRE 110 VYREHVRCLE 120 EWQEAGVNGR 130 YNQVLLVAKP 140 SSESPESLAC 150 PFPEQELESV 160 TVEALFDSGE 170 KPSLAPSLVV 180 LQGSAGTGKT 190 TLARKMVLDW 200 ATGTLYPGRF 210 DYVFYVSCKE 220 VVLLLESKLE 230 QLLFWCCGDN 240 QAPVTEILRQ 250 PERLLFILDG 260 FDELQRPFEE 270 KLKKRGLSPK 280 ESLLHLLIRR 290 HTLPTCSLLI 300 TTRPLALRNL 310 EPLLKQARHV 320 HILGFSEEER 330 ARYFSSYFTD 340 EKQADRAFDI 350 VQKNDILYKA 360 CQVPGICWVV 370 CSWLQGQMER 380 GKVVLETPRN 390 STDIFMAYVS 400 TFLPPDDDGG 410 CSELSRHRVL 420 RSLCSLAAEG 430 IQHQRFLFEE 440 AELRKHNLDG 450 PRLAAFLSSN 460 DYQLGLAIKK 470 FYSFRHISFQ 480 DFFHAMSYLV 490 KEDQSRLGKE 500 SRREVQRLLE 510 VKEQEGNDEM 520 TLTMQFLLDI 530 SKKDSFSNLE 540 LKFCFRISPC 550 LAQDLKHFKE 560 QMESMKHNRT 570 WDLEFSLYEA 580 KIKNLVKGIQ 590 MNNVSFKIKH 600 SNEKKSQSQN 610 LFSVKSSLSH 620 GPKEEQKCPS 630 VHGQKEGKDN 640 IAGTQKEAST 650 GKGRGTEETP KNTYI

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0009898	cytoplasmic side of plasma membrane
Cellular Component	GO:0005829	cytosol
Molecular Function	GO:0005524	ATP binding
Molecular Function	GO:0016887	ATP hydrolysis activity
Molecular Function	GO:0003924	GTPase activity
Biological Process	GO:0002218	activation of innate immune response
Biological Process	GO:0002250	adaptive immune response
Biological Process	GO:0050832	defense response to fungus
Biological Process	GO:0006954	inflammatory response
Biological Process	GO:0045087	innate immune response
Biological Process	GO:1900426	positive regulation of defense response to bacterium
Biological Process	GO:0050729	positive regulation of inflammatory response
Biological Process	GO:0032730	positive regulation of interleukin-1 alpha production
Biological Process	GO:0032755	positive regulation of interleukin-6 production
Biological Process	GO:0032757	positive regulation of interleukin-8 production
Biological Process	GO:0002827	positive regulation of T-helper 1 type immune response
Biological Process	GO:2000318	positive regulation of T-helper 17 type immune response
Biological Process	GO:0050727	regulation of inflammatory response

Reference

[1] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.

[2] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.