Search Results

Overview

Uniprot IDQ86WA6
Protein NameSerine hydrolase BPHL
Gene NameBPHL
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
191 KWSERTRKPLEALYG
208 YFARTCEKWVDGIRQ
217 VDGIRQFKHLPDGNI
243 ALIVHGEKDPLVPRF
257 FHADFIHKHVKGSRL
271 LHLMPEGKHNLHLRF
87 QLKNLNKKLFTVVAW

Function

Specific alpha-amino acid ester serine hydrolase that prefers small, hydrophobic, and aromatic side chains and does not have a stringent requirement for the leaving group other than preferring a primary alcohol (PubMed:12732646, PubMed:15832508, PubMed:18256025, PubMed:25333274, PubMed:32196348). Has homocysteine-thiolactonase activity (in vitro) and may play a significant role in the detoxification of homocysteine thiolactone in vivo (PubMed:25333274). Catalyzes the hydrolytic activation of amino acid ester prodrugs of nucleoside analogs such as valacyclovir and valganciclovir, converting them into their active forms (acyclovir and ganciclovir) (PubMed:15832508, PubMed:18256025)

Protein Sequence

10 MVAVLGGRGV 20 LRLRLLLSAL 30 KPGIHVPRAG 40 PAAAFGTSVT 50 SAKVAVNGVQ 60 LHYQQTGEGD 70 HAVLLLPGML 80 GSGETDFGPQ 90 LKNLNKKLFT 100 VVAWDPRGYG 110 HSRPPDRDFP 120 ADFFERDAKD 130 AVDLMKALKF 140 KKVSLLGWSD 150 GGITALIAAA 160 KYPSYIHKMV 170 IWGANAYVTD 180 EDSMIYEGIR 190 DVSKWSERTR 200 KPLEALYGYD 210 YFARTCEKWV 220 DGIRQFKHLP 230 DGNICRHLLP 240 RVQCPALIVH 250 GEKDPLVPRF 260 HADFIHKHVK 270 GSRLHLMPEG 280 KHNLHLRFAD 290 EFNKLAEDFL Q

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005741 mitochondrial outer membrane
Cellular Component GO:0005739 mitochondrion
Molecular Function GO:0047658 alpha-amino-acid esterase activity
Molecular Function GO:0046872 metal ion binding
Molecular Function GO:0017171 serine hydrolase activity
Biological Process GO:0006520 amino acid metabolic process
Biological Process GO:0050667 homocysteine metabolic process
Biological Process GO:0009636 response to toxic substance
Biological Process GO:0006805 xenobiotic metabolic process

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.