Search Results

Overview

Uniprot ID	Q86WB0
Protein Name	Zinc finger C3HC-type protein 1
Gene Name	ZC3HC1
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
31	SPEGTPQKIRQLIDE

Function

Required for proper positioning of a substantial amount of TPR at the nuclear basket (NB) through interaction with TPR

Protein Sequence

10 MAAPCEGQAF 20 AVGVEKNWGA 30 VVRSPEGTPQ 40 KIRQLIDEGI 50 APEEGGVDAK 60 DTSATSQSVN 70 GSPQAEQPSL 80 ESTSKEAFFS 90 RVETFSSLKW 100 AGKPFELSPL 110 VCAKYGWVTV 120 ECDMLKCSSC 130 QAFLCASLQP 140 AFDFDRYKQR 150 CAELKKALCT 160 AHEKFCFWPD 170 SPSPDRFGML 180 PLDEPAILVS 190 EFLDRFQSLC 200 HLDLQLPSLR 210 PEDLKTMCLT 220 EDKISLLLHL 230 LEDELDHRTD 240 ERKTTIKLGS 250 DIQVHVTACI 260 LSVCGWACSS 270 SLESMQLSLI 280 TCSQCMRKVG 290 LWGFQQIESS 300 MTDLDASFGL 310 TSSPIPGLEG 320 RPERLPLVPE 330 SPRRMMTRSQ 340 DATFSPGSEQ 350 AEKSPGPIVS 360 RTRSWDSSSP 370 VDRPEPEAAS 380 PTTRTRPVTR 390 SMGTGDTPGL 400 EVPSSPLRKA 410 KRARLCSSSS 420 SDTSSRSFFD 430 PTSQHRDWCP 440 WVNITLGKES 450 RENGGTEPDA 460 SAPAEPGWKA 470 VLTILLAHKQ 480 SSQPAETDSM 490 SLSEKSRKVF 500 RIFRQWESLC SC

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0031965	nuclear membrane
Cellular Component	GO:0044615	nuclear pore nuclear basket
Cellular Component	GO:0005654	nucleoplasm
Cellular Component	GO:0005634	nucleus
Molecular Function	GO:0019901	protein kinase binding
Molecular Function	GO:0008270	zinc ion binding
Biological Process	GO:0051301	cell division
Biological Process	GO:0016567	protein ubiquitination

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[3] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[4] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.