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Overview

Uniprot IDQ86WD7
Protein NameSerpin A9
Gene NameSERPINA9
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
278 FVLPSKGKMRQLEQA

Function

Protease inhibitor that inhibits trypsin and trypsin-like serine proteases (in vitro). Inhibits plasmin and thrombin with lower efficiency (in vitro)

Protein Sequence

10 MASYLYGVLF 20 AVGLCAPIYC 30 VSPANAPSAY 40 PRPSSTKSTP 50 ASQVYSLNTD 60 FAFRLYRRLV 70 LETPSQNIFF 80 SPVSVSTSLA 90 MLSLGAHSVT 100 KTQILQGLGF 110 NLTHTPESAI 120 HQGFQHLVHS 130 LTVPSKDLTL 140 KMGSALFVKK 150 ELQLQANFLG 160 NVKRLYEAEV 170 FSTDFSNPSI 180 AQARINSHVK 190 KKTQGKVVDI 200 IQGLDLLTAM 210 VLVNHIFFKA 220 KWEKPFHPEY 230 TRKNFPFLVG 240 EQVTVHVPMM 250 HQKEQFAFGV 260 DTELNCFVLQ 270 MDYKGDAVAF 280 FVLPSKGKMR 290 QLEQALSART 300 LRKWSHSLQK 310 RWIEVFIPRF 320 SISASYNLET 330 ILPKMGIQNV 340 FDKNADFSGI 350 AKRDSLQVSK 360 ATHKAVLDVS 370 EEGTEATAAT 380 TTKFIVRSKD 390 GPSYFTVSFN 400 RTFLMMITNK 410 ATDGILFLGK VENPTKS

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005615 extracellular space
Cellular Component GO:0016020 membrane
Molecular Function GO:0004867 serine-type endopeptidase inhibitor activity

Reference

[1] Cheng Z, Huang H, Li M, Chen Y. Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells.. iScience 27(1):108645. 2024 Jan 19. PMID: 38155775.