Search Results

Overview

Uniprot IDQ86WJ1
Protein NameATP-dependent chromatin remodeler CHD1L
Gene NameCHD1L
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
630 GLVEGSTKRKRVLSP
879 IYYFPRSKSAVLHSQ

Function

ATP-dependent chromatin remodeler that mediates chromatin-remodeling following DNA damage (PubMed:19661379, PubMed:29220652, PubMed:29220653, PubMed:33357431, PubMed:34210977, PubMed:34486521, PubMed:34874266). Recruited to DNA damage sites through interaction with poly-ADP-ribose: specifically recognizes and binds histones that are poly-ADP-ribosylated on serine residues in response to DNA damage (PubMed:19661379, PubMed:29220652, PubMed:29220653, PubMed:34486521, PubMed:34874266). Poly-ADP-ribose-binding activates the ATP-dependent chromatin remodeler activity, thereby regulating chromatin during DNA repair (PubMed:19661379, PubMed:29220652, PubMed:29220653, PubMed:34486521, PubMed:34874266). Catalyzes nucleosome sliding away from DNA breaks in an ATP-dependent manner (PubMed:19661379, PubMed:29220652, PubMed:29220653). Chromatin remodeling activity promotes PARP2 removal from chromatin (PubMed:33275888)

Protein Sequence

10 MERAGATSRG 20 GQAPGFLLRL 30 HTEGRAEAAR 40 VQEQDLRQWG 50 LTGIHLRSYQ 60 LEGVNWLAQR 70 FHCQNGCILG 80 DEMGLGKTCQ 90 TIALFIYLAG 100 RLNDEGPFLI 110 LCPLSVLSNW 120 KEEMQRFAPG 130 LSCVTYAGDK 140 EERACLQQDL 150 KQESRFHVLL 160 TTYEICLKDA 170 SFLKSFPWSV 180 LVVDEAHRLK 190 NQSSLLHKTL 200 SEFSVVFSLL 210 LTGTPIQNSL 220 QELYSLLSFV 230 EPDLFSKEEV 240 GDFIQRYQDI 250 EKESESASEL 260 HKLLQPFLLR 270 RVKAEVATEL 280 PKKTEVVIYH 290 GMSALQKKYY 300 KAILMKDLDA 310 FENETAKKVK 320 LQNILSQLRK 330 CVDHPYLFDG 340 VEPEPFEVGD 350 HLTEASGKLH 360 LLDKLLAFLY 370 SGGHRVLLFS 380 QMTQMLDILQ 390 DYMDYRGYSY 400 ERVDGSVRGE 410 ERHLAIKNFG 420 QQPIFVFLLS 430 TRAGGVGMNL 440 TAADTVIFVD 450 SDFNPQNDLQ 460 AAARAHRIGQ 470 NKSVKVIRLI 480 GRDTVEEIVY 490 RKAASKLQLT 500 NMIIEGGHFT 510 LGAQKPAADA 520 DLQLSEILKF 530 GLDKLLASEG 540 STMDEIDLES 550 ILGETKDGQW 560 VSDALPAAEG 570 GSRDQEEGKN 580 HMYLFEGKDY 590 SKEPSKEDRK 600 SFEQLVNLQK 610 TLLEKASQEG 620 RSLRNKGSVL 630 IPGLVEGSTK 640 RKRVLSPEEL 650 EDRQKKRQEA 660 AAKRRRLIEE 670 KKRQKEEAEH 680 KKKMAWWESN 690 NYQSFCLPSE 700 ESEPEDLENG 710 EESSAELDYQ 720 DPDATSLKYV 730 SGDVTHPQAG 740 AEDALIVHCV 750 DDSGHWGRGG 760 LFTALEKRSA 770 EPRKIYELAG 780 KMKDLSLGGV 790 LLFPVDDKES 800 RNKGQDLLAL 810 IVAQHRDRSN 820 VLSGIKMAAL 830 EEGLKKIFLA 840 AKKKKASVHL 850 PRIGHATKGF 860 NWYGTERLIR 870 KHLAARGIPT 880 YIYYFPRSKS 890 AVLHSQSSSS SSRQLVP

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:0090734 site of DNA damage
Cellular Component GO:0035861 site of double-strand break
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0016887 ATP hydrolysis activity
Molecular Function GO:0140658 ATP-dependent chromatin remodeler activity
Molecular Function GO:0003678 DNA helicase activity
Molecular Function GO:0140566 histone reader activity
Molecular Function GO:0031491 nucleosome binding
Molecular Function GO:0000166 nucleotide binding
Molecular Function GO:0160004 poly-ADP-D-ribose modification-dependent protein binding
Biological Process GO:0006338 chromatin remodeling
Biological Process GO:0006974 DNA damage response
Biological Process GO:0006281 DNA repair

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.