Overview
| Uniprot ID | Q86WR0 |
|---|
| Protein Name | Coiled-coil domain-containing protein 25 |
|---|
| Gene Name | CCDC25 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 160 |
REERNEKKAQIQEMK |
Function
Transmembrane receptor that senses neutrophil extracellular traps (NETs) and triggers the ILK-PARVB pathway to enhance cell motility (PubMed:32528174). NETs are mainly composed of DNA fibers and are released by neutrophils to bind pathogens during inflammation (PubMed:32528174). Formation of NETs is also associated with cancer metastasis, NET-DNA acting as a chemotactic factor to attract cancer cells (PubMed:32528174). Specifically binds NETs on its extracellular region, in particular the 8-OHdG-enriched DNA present in NETs, and recruits ILK, initiating the ILK-PARVB cascade to induce cytoskeleton rearrangement and directional migration of cells (PubMed:32528174). In the context of cancer, promotes cancer metastasis by sensing NETs and promoting migration of tumor cells (PubMed:32528174)
Protein Sequence
10
MVFYFTSSSV
20
NSSAYTIYMG
30
KDKYENEDLI
40
KHGWPEDIWF
50
HVDKLSSAHV
60
YLRLHKGENI
70
EDIPKEVLMD
80
CAHLVKANSI
90
QGCKMNNVNV
100
VYTPWSNLKK
110
TADMDVGQIG
120
FHRQKDVKIV
130
TVEKKVNEIL
140
NRLEKTKVER
150
FPDLAAEKEC
160
RDREERNEKK
170
AQIQEMKKRE
180
KEEMKKKREM
190
DELRSYSSLM
200
KVENMSSNQD
GNDSDEFM
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0012505 |
endomembrane system |
| Cellular Component |
GO:0005886 |
plasma membrane |
| Molecular Function |
GO:0003677 |
DNA binding |
| Biological Process |
GO:2000147 |
positive regulation of cell motility |
Reference
[1] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.