Overview
| Uniprot ID | Q86WX3 |
|---|
| Protein Name | Active regulator of SIRT1 |
|---|
| Gene Name | RPS19BP1 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 46 |
TKAIQAQKLRNSAKG |
| 77 |
DHLRVNLKFLTRTRS |
Function
Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Acts as a chaperone that specifically mediates the integration of RPS19 in state post-A1 (PubMed:34516797). Direct regulator of SIRT1. Enhances SIRT1-mediated deacetylation of p53/TP53, thereby participating in inhibition of p53/TP53-mediated transcriptional activity (PubMed:17964266)
Protein Sequence
10
MSAALLRRGL
20
ELLAASEAPR
30
DPPGQAKPRG
40
APVKRPRKTK
50
AIQAQKLRNS
60
AKGKVPKSAL
70
DEYRKRECRD
80
HLRVNLKFLT
90
RTRSTVAESV
100
SQQILRQNRG
110
RKACDRPVAK
120
TKKKKAEGTV
130
FTEEDFQKFQ
QEYFGS
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005730 |
nucleolus |
| Cellular Component |
GO:0005654 |
nucleoplasm |
| Cellular Component |
GO:0032040 |
small-subunit processome |
| Molecular Function |
GO:0019899 |
enzyme binding |
| Molecular Function |
GO:0003723 |
RNA binding |
| Biological Process |
GO:0042274 |
ribosomal small subunit biogenesis |
Reference
[1] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.