Search Results
Overview
| Uniprot ID | Q86X29 |
|---|---|
| Protein Name | Lipolysis-stimulated lipoprotein receptor |
| Gene Name | LSR |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 638 | SRERRLKKNLALSRE |
Function
Probable role in the clearance of triglyceride-rich lipoprotein from blood. Binds chylomicrons, LDL and VLDL in presence of free fatty acids and allows their subsequent uptake in the cells (By similarity). Maintains epithelial barrier function by recruiting MARVELD2/tricellulin to tricellular tight junctions (By similarity)
Protein Sequence
10
MQQDGLGVGT
20
RNGSGKGRSV
30
HPSWPWCAPR
40
PLRYFGRDAR
50
ARRAQTAAMA
60
LLAGGLSRGL
70
GSHPAAAGRD
80
AVVFVWLLLS
90
TWCTAPARAI
100
QVTVSNPYHV
110
VILFQPVTLP
120
CTYQMTSTPT
130
QPIVIWKYKS
140
FCRDRIADAF
150
SPASVDNQLN
160
AQLAAGNPGY
170
NPYVECQDSV
180
RTVRVVATKQ
190
GNAVTLGDYY
200
QGRRITITGN
210
ADLTFDQTAW
220
GDSGVYYCSV
230
VSAQDLQGNN
240
EAYAELIVLG
250
RTSGVAELLP
260
GFQAGPIEDW
270
LFVVVVCLAA
280
FLIFLLLGIC
290
WCQCCPHTCC
300
CYVRCPCCPD
310
KCCCPEALYA
320
AGKAATSGVP
330
SIYAPSTYAH
340
LSPAKTPPPP
350
AMIPMGPAYN
360
GYPGGYPGDV
370
DRSSSAGGQG
380
SYVPLLRDTD
390
SSVASEVRSG
400
YRIQASQQDD
410
SMRVLYYMEK
420
ELANFDPSRP
430
GPPSGRVERA
440
MSEVTSLHED
450
DWRSRPSRGP
460
ALTPIRDEEW
470
GGHSPRSPRG
480
WDQEPAREQA
490
GGGWRARRPR
500
ARSVDALDDL
510
TPPSTAESGS
520
RSPTSNGGRS
530
RAYMPPRSRS
540
RDDLYDQDDS
550
RDFPRSRDPH
560
YDDFRSRERP
570
PADPRSHHHR
580
TRDPRDNGSR
590
SGDLPYDGRL
600
LEEAVRKKGS
610
EERRRPHKEE
620
EEEAYYPPAP
630
PPYSETDSQA
640
SRERRLKKNL
ALSRESLVV
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005923 | bicellular tight junction |
| Cellular Component | GO:0030054 | cell junction |
| Cellular Component | GO:0042627 | chylomicron |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0034362 | low-density lipoprotein particle |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0070160 | tight junction |
| Cellular Component | GO:0061689 | tricellular tight junction |
| Cellular Component | GO:0034361 | very-low-density lipoprotein particle |
| Biological Process | GO:0010669 | epithelial structure maintenance |
| Biological Process | GO:0060856 | establishment of blood-brain barrier |
| Biological Process | GO:0061436 | establishment of skin barrier |
| Biological Process | GO:0001889 | liver development |
| Biological Process | GO:0035633 | maintenance of blood-brain barrier |
| Biological Process | GO:0061833 | protein localization to tricellular tight junction |
| Biological Process | GO:1904274 | tricellular tight junction assembly |
Reference
[1] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.