Search Results
Overview
| Uniprot ID | Q86X95 |
|---|---|
| Protein Name | Corepressor of RBPJ and splicing regulator |
| Gene Name | CIRSR |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 445 | HPGGTHTKVTQRE** |
Function
May modulate splice site selection during alternative splicing of pre-mRNAs (By similarity). Regulates transcription and acts as corepressor for RBPJ. Recruits RBPJ to the Sin3-histone deacetylase complex (HDAC). Required for RBPJ-mediated repression of transcription
Protein Sequence
10
MGKSFANFMC
20
KKDFHPASKS
30
NIKKVWMAEQ
40
KISYDKKKQE
50
ELMQQYLKEQ
60
ESYDNRLLMG
70
DERVKNGLNF
80
MYEAPPGAKK
90
ENKEKEETEG
100
ETEYKFEWQK
110
GAPREKYAKD
120
DMNIRDQPFG
130
IQVRNVRCIK
140
CHKWGHVNTD
150
RECPLFGLSG
160
INASSVPTDG
170
SGPSMHPSEL
180
IAEMRNSGFA
190
LKRNVLGRNL
200
TANDPSQEYV
210
ASEGEEDPEV
220
EFLKSLTTKQ
230
KQKLLRKLDR
240
LEKKKKKKDR
250
KKKKFQKSRS
260
KHKKHKSSSS
270
SSSSSSSSSS
280
TETSESSSES
290
ESNNKEKKIQ
300
RKKRKKNKCS
310
GHNNSDSEEK
320
DKSKKRKLHE
330
ELSSSHHNRE
340
KAKEKPRFLK
350
HESSREDSKW
360
SHSDSDKKSR
370
THKHSPEKRG
380
SERKEGSSRS
390
HGREERSRRS
400
RSRSPGSYKQ
410
RETRKRAQRN
420
PGEEQSRRND
430
SRSHGTDLYR
440
GEKMYREHPG
450
GTHTKVTQRE
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005813 | centrosome |
| Cellular Component | GO:0016607 | nuclear speck |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0032991 | protein-containing complex |
| Molecular Function | GO:0042826 | histone deacetylase binding |
| Molecular Function | GO:0019901 | protein kinase binding |
| Molecular Function | GO:0044877 | protein-containing complex binding |
| Molecular Function | GO:0003714 | transcription corepressor activity |
| Biological Process | GO:0006351 | DNA-templated transcription |
| Biological Process | GO:0000398 | mRNA splicing, via spliceosome |
| Biological Process | GO:0045892 | negative regulation of DNA-templated transcription |
| Biological Process | GO:0000122 | negative regulation of transcription by RNA polymerase II |
Reference
PMID: N/A