Search Results
Overview
| Uniprot ID | Q86XA0 |
|---|---|
| Protein Name | Histone-arginine methyltransferase METTL23 |
| Gene Name | METTL23 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 147 | SLEALLYKWDMKCVH |
Function
Histone methyltransferase that dimethylates histone H3 at 'Arg-17', forming asymmetric dimethylarginine (H3R17me2a), leading to activate transcription via chromatin remodeling (By similarity). Maternal factor involved in epigenetic chromatin reprogramming of the paternal genome in the zygote: mediates H3R17me2a, promoting histone H3.3 incorporation in the male pronucleus, leading to TET3 recruitment and subsequent DNA demethylation (By similarity)
Protein Sequence
10
MYVWPCAVVL
20
AQYLWFHRRS
30
LPGKAILEIG
40
AGVSLPGILA
50
AKCGAEVILS
60
DSSELPHCLE
70
VCRQSCQMNN
80
LPHLQVVGLT
90
WGHISWDLLA
100
LPPQDIILAS
110
DVFFEPEDFE
120
DILATIYFLM
130
HKNPKVQLWS
140
TYQVRSADWS
150
LEALLYKWDM
160
KCVHIPLESF
170
DADKEDIAES
180
TLPGRHTVEM
190
LVISFAKDSL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0001939 | female pronucleus |
| Cellular Component | GO:0001940 | male pronucleus |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0032991 | protein-containing complex |
| Molecular Function | GO:0140297 | DNA-binding transcription factor binding |
| Molecular Function | GO:0031072 | heat shock protein binding |
| Molecular Function | GO:0035642 | histone H3R17 methyltransferase activity |
| Molecular Function | GO:0035242 | protein-arginine omega-N asymmetric methyltransferase activity |
| Biological Process | GO:0050890 | cognition |
| Biological Process | GO:0044727 | epigenetic programing of male pronucleus |
| Biological Process | GO:0044725 | epigenetic programming in the zygotic pronuclei |
| Biological Process | GO:0040029 | epigenetic regulation of gene expression |
| Biological Process | GO:0032259 | methylation |
| Biological Process | GO:0045944 | positive regulation of transcription by RNA polymerase II |
Reference
[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.