Search Results
Overview
| Uniprot ID | Q86XE5 |
|---|---|
| Protein Name | 4-hydroxy-2-oxoglutarate aldolase, mitochondrial |
| Gene Name | HOGA1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 102 | RVRQAMPKNRLLLAG |
Function
Catalyzes the final step in the metabolic pathway of hydroxyproline
Protein Sequence
10
MLGPQVWSSV
20
RQGLSRSLSR
30
NVGVWASGEG
40
KKVDIAGIYP
50
PVTTPFTATA
60
EVDYGKLEEN
70
LHKLGTFPFR
80
GFVVQGSNGE
90
FPFLTSSERL
100
EVVSRVRQAM
110
PKNRLLLAGS
120
GCESTQATVE
130
MTVSMAQVGA
140
DAAMVVTPCY
150
YRGRMSSAAL
160
IHHYTKVADL
170
SPIPVVLYSV
180
PANTGLDLPV
190
DAVVTLSQHP
200
NIVGMKDSGG
210
DVTRIGLIVH
220
KTRKQDFQVL
230
AGSAGFLMAS
240
YALGAVGGVC
250
ALANVLGAQV
260
CQLERLCCTG
270
QWEDAQKLQH
280
RLIEPNAAVT
290
RRFGIPGLKK
300
IMDWFGYYGG
310
PCRAPLQELS
320
PAEEEALRMD
FTSNGWL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005759 | mitochondrial matrix |
| Cellular Component | GO:0005739 | mitochondrion |
| Molecular Function | GO:0106009 | (4S)-4-hydroxy-2-oxoglutarate aldolase activity |
| Molecular Function | GO:0008700 | (R,S)-4-hydroxy-2-oxoglutarate aldolase activity |
| Molecular Function | GO:0042803 | protein homodimerization activity |
| Biological Process | GO:0009436 | glyoxylate catabolic process |
| Biological Process | GO:0046487 | glyoxylate metabolic process |
| Biological Process | GO:0033609 | oxalate metabolic process |
| Biological Process | GO:0042866 | pyruvate biosynthetic process |
| Biological Process | GO:0019470 | trans-4-hydroxy-L-proline catabolic process |
Reference
[1] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.